[Effect of Hypecoum erectum extract on morphofunctional state of the liver in rats with tetracycline-associated hepatitis].

Publisher: Izdatelstvo Meditsina Country of Publication: Russia (Federation) NLM ID: 8803688 Publication Model: Print Cited Medium: Print ISSN: 0235-2990 (Print) Linking ISSN: 02352990 NLM ISO Abbreviation: Antibiot Khimioter Subsets: MEDLINE

Publication: Moskva : Izdatelstvo Meditsina
Original Publication: Moskva : Meditsina, c1988-

Antioxidants/*pharmacology ; Chemical and Drug Induced Liver Injury/*drug therapy ; Liver/*drug effects ; Papaveraceae/*chemistry ; Plant Extracts/*chemistry ; Protective Agents/*pharmacology; Adenosine Triphosphate/metabolism ; Animals ; Antioxidants/isolation & purification ; Catalase/metabolism ; Chemical and Drug Induced Liver Injury/metabolism ; Chemical and Drug Induced Liver Injury/physiopathology ; Drug Administration Schedule ; Female ; Glutathione/metabolism ; Lactic Acid/metabolism ; Lipid Peroxidation/drug effects ; Liver/metabolism ; Liver/physiopathology ; Male ; Malondialdehyde/metabolism ; Protective Agents/isolation & purification ; Pyruvic Acid/metabolism ; Rats ; Rats, Wistar ; Tetracycline

The effect of Hypecoum erectum L. extract on the morphofunctional condition of the liver in rats with experimental tetracycline-associated hepatitis was studied. The experiment included 40 albino rats Wistar. The animals treated with tetracycline hydrochloride (1.0 g/kg body weight) were exposed to the extract in a dose of 50 mg/kg for 5 days. On the 7th day of the experiment the following indices were determined: malonic dialdehyde concentration, catalase activity, the levels of ATP, pyruvate and lactate in the liver homogenate, as well as the blood levels of reduced glutathione. The liver pathomorphological investigation was applied. The H. erectum extract was shown to inhibit lipid peroxidation, to increase the activity of the host endogenous antioxidant system, to normalize the hepatocyte energy provision and to limit the liver degeneration.

0 (Antioxidants)
0 (Plant Extracts)
0 (Protective Agents)
33X04XA5AT (Lactic Acid)
4Y8F71G49Q (Malondialdehyde)
8558G7RUTR (Pyruvic Acid)
8L70Q75FXE (Adenosine Triphosphate)
EC 1.11.1.6 (Catalase)
F8VB5M810T (Tetracycline)
GAN16C9B8O (Glutathione)

Date Created: 20150516 Date Completed: 20150602 Latest Revision: 20161125

20221213

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