Follicle-stimulating hormone associates with prediabetes and diabetes in postmenopausal women.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9200299 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-5233 (Electronic) Linking ISSN: 09405429 NLM ISO Abbreviation: Acta Diabetol Subsets: MEDLINE
    • Publication Information:
      Publication: Berlin : Springer Verlag
      Original Publication: Berlin : Springer International, c1991-
    • Subject Terms:
      Diabetes Mellitus, Type 2/*metabolism ; Follicle Stimulating Hormone/*blood ; Postmenopause/*metabolism ; Prediabetic State/*metabolism; Aged ; Aged, 80 and over ; Blood Glucose/metabolism ; China/epidemiology ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/epidemiology ; Female ; Glycated Hemoglobin/analysis ; Hormones/blood ; Humans ; Insulin Resistance ; Middle Aged ; Prediabetic State/epidemiology ; Prevalence ; Risk Factors ; Socioeconomic Factors ; Waist Circumference
    • Abstract:
      Aims: No study explores the association between follicle-stimulating hormone (FSH) and glucose metabolism in general women. We aim to investigate whether the variation of FSH is associated with prediabetes and diabetes in postmenopausal women.
      Methods: Our data were from survey on prevalence in East China for metabolic diseases and risk factors in 2014. Thousand six hundred and ten postmenopausal women at the age of 55-89 who were not using hormone replacement therapy were selected. Prediabetes and diabetes were defined according to American Diabetes Association 2014 criteria. FSH, luteinizing hormone, total testosterone and estradiol were measured by chemiluminescence. Multinomial logistic analyses were used for the association of FSH with prediabetes and diabetes, and linear regression for the association of FSH with fasting plasma glucose (FPG) and HbA1c.
      Results: Among the participants, 778 (48.3 %) had prediabetes and 121 (7.5 %) had newly diagnosed diabetes. In linear regression, after full adjustment for demographic variables, metabolic factors, E2 and LH, FSH was associated with FPG and HbA1c (P < 0.05). In logistic regression, increased quartiles of FSH were associated with significantly decreased odds ratios of prediabetes and diabetes (P for trend <0.01). This association was attenuated by waist circumference and HOMA-IR, but persisted in fully adjusted model (P for trend <0.05) in which, for the lowest compared with the highest quartile of FSH, the odds ratios of prediabetes and diabetes were 1.93 (95 % CI 1.21-3.08; P < 0.01) and 3.02 (95 % CI 1.10-8.31; P < 0.05), respectively.
      Conclusions: Low FSH was associated with prediabetes and diabetes in postmenopausal women. The associations might be partially explained by adiposity and insulin resistance.
    • References:
      J Clin Endocrinol Metab. 2009 Sep;94(9):3259-64. (PMID: 19549740)
      J Clin Endocrinol Metab. 2009 Nov;94(11):4127-35. (PMID: 19789205)
      J Natl Cancer Inst. 2003 Aug 20;95(16):1218-26. (PMID: 12928347)
      Endocrinology. 2003 Nov;144(11):4868-75. (PMID: 12960020)
      World Health Organ Tech Rep Ser. 1996;866:1-107. (PMID: 8942292)
      J Clin Endocrinol Metab. 2011 Sep;96(9):2643-51. (PMID: 21896895)
      Eur J Epidemiol. 2005;20(12):1015-22. (PMID: 16331433)
      J Clin Endocrinol Metab. 2004 Dec;89(12):6039-47. (PMID: 15579756)
      J Clin Endocrinol Metab. 2011 Mar;96(3):746-54. (PMID: 21159842)
      Obesity (Silver Spring). 2015 Jan;23(1):228-33. (PMID: 25294746)
      JAMA. 2013 Sep 4;310(9):948-59. (PMID: 24002281)
      J Clin Endocrinol Metab. 2007 Apr;92(4):1289-95. (PMID: 17244779)
      Clin Exp Reprod Med. 2014 Jun;41(2):86-91. (PMID: 25045633)
      Zhonghua Fu Chan Ke Za Zhi. 1989 May;24(3):147-9, 189. (PMID: 2530066)
      Cancer Epidemiol Biomarkers Prev. 2006 Dec;15(12):2502-7. (PMID: 17164376)
      Int J Obes (Lond). 2008 Jul;32(7):1035-41. (PMID: 18458678)
      Indian J Clin Biochem. 2013 Apr;28(2):169-76. (PMID: 24426204)
      Obesity (Silver Spring). 2006 Nov;14(11):1954-60. (PMID: 17135611)
      Biomark Med. 2014;8(7):921-30. (PMID: 25307546)
      Menopause. 2010 Jul;17(4):718-26. (PMID: 20216473)
      Maturitas. 2012 Dec;73(4):354-60. (PMID: 23026018)
      Diabetologia. 2007 Oct;50(10):2076-84. (PMID: 17701157)
      Diabetes. 2003 Jul;52(7):1799-805. (PMID: 12829649)
      Clin Biochem. 2012 Jun;45(9):703-6. (PMID: 22449337)
      Rocz Akad Med Bialymst. 2003;48:131-4. (PMID: 14737959)
      Br J Nutr. 2014 Nov 28;112(10):1735-44. (PMID: 25300318)
      Medicina (B Aires). 2003;63(1):28-32. (PMID: 12673957)
      Asia Pac J Public Health. 2015 Mar;27(2):NP457-67. (PMID: 23165487)
    • Contributed Indexing:
      Keywords: Diabetes; Follicle-stimulating hormone; Postmenopause; Women
    • Accession Number:
      0 (Blood Glucose)
      0 (Glycated Hemoglobin A)
      0 (Hormones)
      9002-68-0 (Follicle Stimulating Hormone)
    • Publication Date:
      Date Created: 20150512 Date Completed: 20161213 Latest Revision: 20221207
    • Publication Date:
      20221213
    • Accession Number:
      PMC4826410
    • Accession Number:
      10.1007/s00592-015-0769-1
    • Accession Number:
      25959422