Effect of genetic variations on ticagrelor plasma levels and clinical outcomes.

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  • Additional Information
    • Corporate Authors:
      PLATO Investigators
    • Source:
      Publisher: Oxford University Press Country of Publication: England NLM ID: 8006263 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-9645 (Electronic) Linking ISSN: 0195668X NLM ISO Abbreviation: Eur Heart J Subsets: MEDLINE
    • Publication Information:
      Publication: 2005- : Oxford : Oxford University Press
      Original Publication: London, Saunders [etc.]
    • Subject Terms:
      Acute Coronary Syndrome/*drug therapy ; Adenosine/*analogs & derivatives ; Cytochrome P-450 CYP3A/*genetics ; Glucuronosyltransferase/*genetics ; Organic Anion Transporters/*genetics ; Purinergic P2Y Receptor Antagonists/*pharmacokinetics; Acute Coronary Syndrome/blood ; Acute Coronary Syndrome/genetics ; Adenosine/blood ; Adenosine/metabolism ; Adenosine/pharmacokinetics ; Adult ; Female ; Genome-Wide Association Study ; Genotype ; Humans ; Liver-Specific Organic Anion Transporter 1 ; Male ; Middle Aged ; Polymorphism, Single Nucleotide/genetics ; Purinergic P2Y Receptor Antagonists/blood ; Ticagrelor ; Treatment Outcome
    • Abstract:
      Aims: Ticagrelor, a direct-acting P2Y12-receptor antagonist, is rapidly absorbed and partly metabolized to the major metabolite AR-C124910XX (ARC). To identify single-nucleotide polymorphisms (SNPs) associated with pharmacokinetics of ticagrelor and clinical outcomes, we performed a genome-wide association study (GWAS) in patients treated with ticagrelor in the PLATO trial.
      Methods and Results: A two-stage design was used for the GWAS with discovery (discovery phase: n = 1812) and replication cohorts (replication phase: n = 1941). The steady-state area under the curve (AUCss) values, estimated by the population pharmacokinetic (PK) models, were log transformed and analysed on a genome-wide scale using linear regression. SNPs were analysed against clinical events using Cox-regression in 4990 patients. An SNP (rs113681054) in SLCO1B1 was associated with levels of ticagrelor (P = 1.1 × 10(-6)) and ARC (P = 4.6 × 10(-13)). This SNP is in linkage disequilibrium with a functional variant (rs4149056) that results in decreased OATP1B1 transporter activity. Ticagrelor levels were also associated with two independent SNPs (rs62471956, P = 7.7 × 10(-15) and rs56324128, P = 9.7 × 10(-12)) in the CYP3A4 region. Further, ARC levels were associated with rs61361928 (P = 3.0 × 10(-14)) in UGT2B7. At all loci, the effects were small. None of the identified SNPs that affected ticagrelor PK were associated with the primary composite outcome (cardiovascular death myocardial infarction, and stroke), non-CABG-related bleeds or investigator-reported dyspnoea.
      Conclusion: In patients with ACS, ticagrelor pharmacokinetics is influenced by three genetic loci (SLCO1B1, UGT2B7, and CYP3A4). However, the modest genetic effects on ticagrelor plasma levels did not translate into any detectable effect on efficacy or safety during ticagrelor treatment.
      Clinical Trial Registration: NCT00391872.
      (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: [email protected].)
    • Comments:
      Comment in: Eur Heart J. 2019 Jun 21;40(24):e1-e3. (PMID: 26084685)
    • Contributed Indexing:
      Keywords: Acute Coronary Syndrome; Antiplatelet Treatment; Clopidogrel; Genome-wide association study; Pharmacogenetics; Ticagrelor
    • Molecular Sequence:
      ClinicalTrials.gov NCT00391872
    • Accession Number:
      0 (AR C124910XX)
      0 (Liver-Specific Organic Anion Transporter 1)
      0 (Organic Anion Transporters)
      0 (Purinergic P2Y Receptor Antagonists)
      0 (SLCO1B1 protein, human)
      EC 1.14.14.1 (Cytochrome P-450 CYP3A)
      EC 1.14.14.55 (CYP3A4 protein, human)
      EC 2.4.1.- (UGT2B7 protein, human)
      EC 2.4.1.17 (Glucuronosyltransferase)
      GLH0314RVC (Ticagrelor)
      K72T3FS567 (Adenosine)
    • Publication Date:
      Date Created: 20150504 Date Completed: 20160504 Latest Revision: 20181211
    • Publication Date:
      20221213
    • Accession Number:
      10.1093/eurheartj/ehv116
    • Accession Number:
      25935875