[Collapsing variant of focal segmental glomerulosclerosis by parvovirus B19: case report].

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  • Additional Information
    • Transliterated Title:
      Glomeruloesclerose segmentar e focal (GESF) colapsante associada ao parvovírus B19: relato de caso.
    • Source:
      Publisher: Sociedade Brasileira de Nefrologia Country of Publication: Brazil NLM ID: 9426946 Publication Model: Print Cited Medium: Internet ISSN: 2175-8239 (Electronic) Linking ISSN: 01012800 NLM ISO Abbreviation: J Bras Nefrol Subsets: MEDLINE
    • Publication Information:
      Publication: São Paulo : Sociedade Brasileira de Nefrologia
      Original Publication: São Paulo, Brazil : Associação Medica Brasileira
    • Subject Terms:
      Parvovirus B19, Human*; Glomerulosclerosis, Focal Segmental/*classification ; Glomerulosclerosis, Focal Segmental/*virology ; Parvoviridae Infections/*complications; Adult ; Female ; Humans
    • Abstract:
      Objective: To describe the clinical and laboratory profile of focal segmental glomerulosclerosis (FSGS) of the collapsing subtype in association with infection by parvovirus B19 (PVB19).
      Case Report: Female patient, 37 years old, mulatto, developed pharyngalgia and fever with partial improvement after penicillin. After one week we observed reduced urinary output and lower limb edema. Smoker, family and personal history negative for hypertension, diabetes or kidney disease. Patient presented with olyguria, hypertension and edema, also hypochromic microcytic hypoproliferative anemia, nephritic range proteinuria, microscopic hematuria and renal dysfunction. All rheumatologic investigation, HIV and hepatitis serology were negative. Unremarkable renal ultrasound. PCR positive for PVB19 in bone marrow aspirate and blood and renal biopsy conclusive of collapsing FSGS subtype. Spontaneous remission occurred within two weeks of the profile. The blood PVB19 PCR was repeated within a month and resulted negative. This finding demonstrated PVB19 acute infection or viral reactivation in association with collapsing FSGS.
      Conclusion: There is demonstrated the temporal association of PVB19 viremia and collapsing FSGS, due primary infection or viral reactivation. The association of collapsing FSGS and PVB19 is described in the literature, demonstrating virus presence in kidney tissue, but the real relationship of virus in the pathogenesis of this glomerulopathy remains unclear.
    • Publication Date:
      Date Created: 20150430 Date Completed: 20170309 Latest Revision: 20170309
    • Publication Date:
      20250114
    • Accession Number:
      10.5935/0101-2800.20150017
    • Accession Number:
      25923759