Item request has been placed!
×
Item request cannot be made.
×
Processing Request
[Synthesis and cytotoxicity of triterpenoid seven members cyclic amines].
Item request has been placed!
×
Item request cannot be made.
×
Processing Request
- Additional Information
- Source:
Publisher: Nauka Country of Publication: Russia (Federation) NLM ID: 7804941 Publication Model: Print Cited Medium: Print ISSN: 0132-3423 (Print) Linking ISSN: 01323423 NLM ISO Abbreviation: Bioorg Khim Subsets: MEDLINE
- Publication Information:
Original Publication: Moskva, Nauka
- Subject Terms:
- Abstract:
Synthesis of 3-deoxy-3a-homo-3a-aza-derivatives of betulin and erythrodiol from betulonic and oleanonic acids was carried out. The most antineoplastic activity with a wide range of action at in vitro testing showed 3-deoxy-3a-homo-3a-aza-28-hydroxy-12(13)-oleanene, which by results of profound studying could be recommended for in vivo investigation. Its modification in the C28 position by introduction of amethoxycinnamoyl fragment led to a loss of antineoplastic activity. 3-Deoxy-3a-homo-3a-aza-derivatives of betulin (3-(aminopropyl)-, 28-(2-carboxyethyl)carboxy-, and 28-cinnamoyloxy-) showed moderate antineoplastic activity in the case of Colon Cancer, Breast Cancer and Leukemia cell lines.
- Accession Number:
0 (Antineoplastic Agents)
0 (Antiviral Agents)
0 (Triterpenes)
0 (oleanonic acid)
3VWF903FSS (erythrodiol)
6SMK8R7TGJ (Oleanolic Acid)
6W70HN7X7O (betulin)
PJY633525U (Adamantane)
- Publication Date:
Date Created: 20150422 Date Completed: 20150603 Latest Revision: 20191027
- Publication Date:
20231215
- Accession Number:
10.1134/s106816201402006x
- Accession Number:
25895342
No Comments.