[Is there a place for thrombin generation assay in routine clinical laboratory?].

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  • Additional Information
    • Transliterated Title:
      Quelle place pour le test de génération de thrombine au sein du laboratoire de biologie clinique ?
    • Source:
      Publisher: John Libbey Eurotext Country of Publication: France NLM ID: 2984690R Publication Model: Print Cited Medium: Internet ISSN: 1950-6112 (Electronic) Linking ISSN: 00033898 NLM ISO Abbreviation: Ann Biol Clin (Paris) Subsets: MEDLINE
    • Publication Information:
      Publication: Montrouge : John Libbey Eurotext
      Original Publication: Paris : Expansion scientifique française.
    • Subject Terms:
      Blood Coagulation Disorders/*diagnosis ; Blood Coagulation Tests/*methods ; Diagnostic Tests, Routine/*methods ; Thrombin/*metabolism; Blood Coagulation Disorders/blood ; Blood Coagulation Tests/statistics & numerical data ; Clinical Laboratory Services/standards ; Diagnostic Tests, Routine/statistics & numerical data ; Humans ; Partial Thromboplastin Time/methods ; Partial Thromboplastin Time/statistics & numerical data ; Thrombin/analysis
    • Abstract:
      Laboratory diagnosis of coagulopathies primarily relies on assays selectively exploring either the extrinsic (PT), the intrinsic (aPTT) or the common (TT) pathway of the coagulation system. Although these tests are very useful to rapidly identify severe coagulation disorders or to monitor anticoagulant therapy, they only poorly correlate with the clinical manifestations. Global assays that evaluate the whole coagulation process could potentially more accurately reflect the hemorrhagic or thrombotic phenotype of an individual. Thrombin generation assay (TGA), first described in the 1950's, has been developed and automated in the 1990's. This technique is widely used in fundamental research but has yet failed to integrate clinical laboratories. In this article, we describe TGA and review its clinical applications. Laboratory aspects and technical issues will also be discussed.
    • Contributed Indexing:
      Keywords: ETP; TGA; assays; coagulation; thrombin
    • Accession Number:
      EC 3.4.21.5 (Thrombin)
    • Publication Date:
      Date Created: 20150408 Date Completed: 20160412 Latest Revision: 20181202
    • Publication Date:
      20240829
    • Accession Number:
      10.1684/abc.2014.1018
    • Accession Number:
      25847735