[Total ginsenosides fought against right ventricular hypertrophy through inhibiting calcineurin signal pathway].

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  • Author(s): Qin N; Wei LW; Huang XN
  • Source:
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine [Zhongguo Zhong Xi Yi Jie He Za Zhi] 2015 Jan; Vol. 35 (1), pp. 93-7.
  • Publication Type:
    Journal Article
  • Language:
    Chinese
  • Additional Information
    • Source:
      Publisher: Gai yan jiu yuan Country of Publication: China NLM ID: 9211576 Publication Model: Print Cited Medium: Print ISSN: 1003-5370 (Print) Linking ISSN: 10035370 NLM ISO Abbreviation: Zhongguo Zhong Xi Yi Jie He Za Zhi Subsets: MEDLINE
    • Publication Information:
      Publication: Beijing : Gai yan jiu yuan
      Original Publication: Beijing : Gai yan jiu yuan, 1992-
    • Subject Terms:
      Calcineurin/*metabolism ; Calcineurin Inhibitors/*therapeutic use ; Ginsenosides/*therapeutic use ; Hypertrophy, Right Ventricular/*drug therapy; Animals ; Atrial Natriuretic Factor ; Heart Ventricles ; Hypertrophy, Right Ventricular/metabolism ; Male ; Monocrotaline ; Myocardium ; Myocytes, Cardiac ; RNA, Messenger ; Rats ; Rats, Sprague-Dawley ; Signal Transduction
    • Abstract:
      Objective: To observe the effect of total ginsenosides (TG) on monocrotaline (MCT) induced right ventricular hypertrophy rats, and to explore its correlation with calcineurin (CaN) pathway.
      Methods: Fifty male Sprague Dawley rats were randomly divided into the normal control group, the MCT model group, and the low, middle, high dose TG treatment groups, 10 in each group. All medication was performed by peritoneal injection for 18 days. Right ventricular peak systolic pressure (RVSP), right ventricular hypertrophy index (RVHI), and right ventricular weight/body weight (RVW/BW) were measured. Intracellular free calcium concentrations were measured by Ca2+ fluorescence indicator Fura2/AM. The atrial natriuretic factor (ANF) and CaN mRNA expression of the myocardial tissue were quantitatively analyzed by Real-time PCR. The protein expression of CaN was detected by Western blot.
      Results: Compared with the MCT model group, preventive treatment of TG at the 3 doses could significantly reduce RVSP, RVHI, RVW/BW, and ANF mRNA expression, and decrease Ca2+ concentration in myocardial cells, CaN mRNA and protein expression in the myocardial tissue.
      Conclusion: TG could obviously improve MCT-induced right ventricular hypertrophy, which was possibly achieved through suppressing MCT-activated CaN signal transduction.
    • Accession Number:
      0 (Calcineurin Inhibitors)
      0 (Ginsenosides)
      0 (RNA, Messenger)
      73077K8HYV (Monocrotaline)
      85637-73-6 (Atrial Natriuretic Factor)
      EC 3.1.3.16 (Calcineurin)
    • Publication Date:
      Date Created: 20150321 Date Completed: 20150908 Latest Revision: 20181202
    • Publication Date:
      20231215
    • Accession Number:
      25790682