Molecular surveillance of candidemia due to Candida albicans among cancer patients during 2009 to 2013 by microsatellite typing.

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  • Additional Information
    • Source:
      Publisher: Academic Press Country of Publication: England NLM ID: 8606191 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1208 (Electronic) Linking ISSN: 08824010 NLM ISO Abbreviation: Microb Pathog Subsets: MEDLINE
    • Publication Information:
      Original Publication: London ; Orlando : Academic Press, c1986-
    • Subject Terms:
      Mycological Typing Techniques*; Candida albicans/*classification ; Candida albicans/*isolation & purification ; Candidemia/*epidemiology ; Candidemia/*microbiology ; Neoplasms/*complications; Candida albicans/genetics ; China/epidemiology ; Epidemiological Monitoring ; Genotype ; Hospitals, University ; Humans ; Microsatellite Repeats ; Molecular Epidemiology ; Molecular Typing ; Risk Factors
    • Abstract:
      Background: Since the high morbidity and mortality of candidemia among cancer patients, the epidemiology has been underlined. In recent years, Candida species genotyping has been established, which could provide detail characteristics of epidemiology and has been underscored for candidemia preventing strategies.
      Methods: Data of cancer patients with candidemia and hospitalized in Tianjin Medical University Cancer Institute and Hospital (TMUCIH) during 2009-2013 were reviewed. Species identification was carried out by using VITEK-2 Compact. Microsatellite typing was performed for molecular analysis. SPSS 20.0 and MVSP 3.22 software were used for statistical and clustering analysis, respectively.
      Results: Total of 36 isolates of Candida albicans were recovered from 36 cancer patients with nosocomial candidemia in TMUCIH during the period of 2009-2013 included in the study. Total of 17 genotypes were identified and 2 of them were endemic genotypes, which caused 21 (58.3%) of 36 episodes of candidemia. Hepatobiliary oncology, ICU and gastrointestinal oncology were the main wards of infections due to endemic strains. Gastrointestinal cancer and insertion of a nasogastric tube were the predictors of infections caused by endemic strains (p = 0.014 and p = 0.041, respectively). For the 36 cases, crude mortality was up to 30.6%, and there was no significant difference between infections due to endemic and non-endemic strains (p = 0.077).
      Conclusions: This study proved that endemic stains of C. albicans could exist for a long period and mainly in a few wards. Patients with gastrointestinal cancer or nasogastric tube insertion were more sensitive to endemic C. albicans.
      (Copyright © 2015 Elsevier Ltd. All rights reserved.)
    • Contributed Indexing:
      Keywords: Cancer patient; Candida albicans; Candidemia; Molecular epidemiology; Risk factor
    • Publication Date:
      Date Created: 20150315 Date Completed: 20151214 Latest Revision: 20220408
    • Publication Date:
      20240829
    • Accession Number:
      10.1016/j.micpath.2015.03.005
    • Accession Number:
      25769820