Survival of renal transplant patients: data from a tertiary care center in Turkey.

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  • Additional Information
    • Source:
      Publisher: Elsevier Science Inc Country of Publication: United States NLM ID: 0243532 Publication Model: Print Cited Medium: Internet ISSN: 1873-2623 (Electronic) Linking ISSN: 00411345 NLM ISO Abbreviation: Transplant Proc Subsets: MEDLINE
    • Publication Information:
      Publication: New York, N.Y. : Elsevier Science Inc.
      Original Publication: New York Stratton.
    • Subject Terms:
      Developing Countries* ; Graft Survival* ; Tertiary Care Centers*; Kidney Failure, Chronic/*mortality ; Kidney Failure, Chronic/*surgery ; Kidney Transplantation/*mortality; Adult ; Aged ; Creatinine/blood ; Female ; Humans ; Immunosuppression Therapy ; Immunosuppressive Agents/therapeutic use ; Kidney Transplantation/adverse effects ; Living Donors ; Male ; Middle Aged ; Mycophenolic Acid/therapeutic use ; Retrospective Studies ; Survival Analysis ; Survival Rate ; Tacrolimus/therapeutic use ; Turkey
    • Abstract:
      Objective: Data on transplantation survival is widely available for developed countries where cadaveric transplantation is the dominant transplantation type. We aimed to assess patient and graft survival and to determine the possible factors affecting graft survival in a developing country where kidney transplantations were mainly performed from living donors.
      Methods: We retrospectively analyzed data from 427 adult kidney transplantations performed at our center from January 1990 to November 2010. We collected data from patient files, including characteristics of the recipients and donors, transplantation-related factors, post-transplantation features, causes of graft loss, and patient death. The Kaplan-Meier method was used to analyze survival, and Cox regression analysis was used to evaluate the effects of multiple factors on graft survival.
      Results: Most of the recipients (82.6%) received their organs from living donors. One-year and 5-year graft survival rates were 87.5% and 78.3%, respectively, where the 5-year graft survival rates were 87.1% for living donors and 74.8% for cadaveric donors. The 1-year and 5-year patient survival rates were 90.9% and 88.9%, respectively. Univariate analysis showed that predictors for better graft survival were serum creatinine levels <1.5 mg/dL at 1 month after transplantation, proteinuria <500 mg/d at 1 year after transplantation, use of tacrolimus and mycophenolic acid derivative-based immunosuppression at baseline, living-donor transplantation, and transplantations performed in the years 2000-2010.
      Conclusions: We report data on kidney transplantation in an emerging country where living-donor transplantation constitutes a large proportion of kidney transplant activities. Modern immunosuppressive medications help to achieve a better survival. Our 5-year results are similar to those of developed countries.
      (Copyright © 2015 Elsevier Inc. All rights reserved.)
    • Accession Number:
      0 (Immunosuppressive Agents)
      AYI8EX34EU (Creatinine)
      HU9DX48N0T (Mycophenolic Acid)
      WM0HAQ4WNM (Tacrolimus)
    • Publication Date:
      Date Created: 20150315 Date Completed: 20150930 Latest Revision: 20211203
    • Publication Date:
      20221213
    • Accession Number:
      10.1016/j.transproceed.2014.10.054
    • Accession Number:
      25769571