Now you see me, now you don't: the interaction of Salmonella with innate immune receptors.

Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101190261 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1740-1534 (Electronic) Linking ISSN: 17401526 NLM ISO Abbreviation: Nat Rev Microbiol Subsets: MEDLINE

Original Publication: London, UK : Nature Pub. Group, c2003-

Immunity, Innate*; Receptors, Immunologic/*immunology ; Salmonella enterica/*physiology ; Salmonella typhi/*physiology ; Typhoid Fever/*immunology; Animals ; Humans ; Salmonella enterica/classification ; Salmonella enterica/genetics ; Salmonella typhi/genetics ; Typhoid Fever/microbiology ; Virulence Factors/genetics

Salmonella enterica serovars are associated with an estimated 1 million deaths annually and are also useful model organisms for investigating the mechanisms of host-bacterium interactions. The insights gained from studies on non-typhoidal Salmonella (NTS) serovars have provided a fascinating overview of the mechanisms by which the innate immune system detects and responds to bacterial pathogens. However, specific virulence factors and changes in virulence gene regulation in S. enterica subsp. enterica serovar Typhi alter the innate immune responses to this pathogen. In this Review, we compare and contrast the interactions of S. Typhi and NTS serovars with host innate immune receptors and discuss why the disease manifestations associated with S. Typhi infection differ considerably from those associated with the closely related NTS serovars.

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0 (Receptors, Immunologic)
0 (Virulence Factors)

Date Created: 20150310 Date Completed: 20150601 Latest Revision: 20230120

20231215

10.1038/nrmicro3428

25749454