Correlation of clinical profile and specific histopathological features of temporal artery biopsies.

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  • Author(s): Stacy RC;Stacy RC;Stacy RC;Stacy RC; Gilbert AL; Rizzo JF 3rd
  • Source:
    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society [J Neuroophthalmol] 2015 Jun; Vol. 35 (2), pp. 127-33.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9431308 Publication Model: Print Cited Medium: Internet ISSN: 1536-5166 (Electronic) Linking ISSN: 10708022 NLM ISO Abbreviation: J Neuroophthalmol Subsets: MEDLINE
    • Publication Information:
      Publication: <1999->: Hagerstown, MD : Lippincott Williams & Wilkins
      Original Publication: New York, NY : Raven Press, c1994-
    • Subject Terms:
      Giant Cell Arteritis/*complications ; Giant Cell Arteritis/*diagnosis ; Temporal Arteries/*pathology ; Vision Disorders/*etiology; Adrenal Cortex Hormones/therapeutic use ; Aged ; Antigens, CD ; Biopsy ; Female ; Giant Cell Arteritis/drug therapy ; Humans ; Male ; Retrospective Studies ; Statistics as Topic
    • Abstract:
      Background: This study sought to correlate the clinical features of patients with giant cell arteritis (GCA) who present with ophthalmic symptoms and signs, with 2 specific histopathological findings-the presence of giant cells and arterial wall neoangiogenesis. The goal was to assess if these pathological features might be useful in guiding the approach to patient management.
      Methods: Medical charts were retrospectively reviewed from 58 patients who underwent a temporal artery biopsy at a single institution. Detailed information was collected about the clinical presentation and course, with an emphasis on visual function. Histopathological and immunohistochemical techniques were used to examine temporal artery biopsies for evidence of inflammation. Correlations were made between the clinical data and the presence of giant cells and neoangiogenesis.
      Results: Twenty-one (34%) biopsies were positive for inflammation consistent with GCA. Although the percentage of positive biopsies with giant cells was high, neither the presence of giant cells nor neoangiogenesis was predictive of a patient's presenting visual symptoms, severity and bilaterality of vision loss, other ophthalmic manifestations of GCA, presence of headache or jaw claudication, or erythrocyte sedimentation rate. Giant cells were more common in patients with recent weight loss. Immunohistochemistry confirmed diagnoses but did not alter the clinical course or treatment plan.
      Conclusions: There was no correlation between the clinical, specifically visual, features of GCA and the presence or absence of giant cells or neoangiogenesis in temporal artery biopsy specimens. Although the presence of neoangiogenesis may be important in the pathogenesis of GCA, our study showed no correlation between this finding and the clinical course.
    • Accession Number:
      0 (Adrenal Cortex Hormones)
      0 (Antigens, CD)
    • Publication Date:
      Date Created: 20150306 Date Completed: 20160210 Latest Revision: 20150519
    • Publication Date:
      20231215
    • Accession Number:
      10.1097/WNO.0000000000000213
    • Accession Number:
      25742197