Fibrosis-related biomarkers and large and small vessel disease: the Cardiovascular Health Study.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Ireland NLM ID: 0242543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1484 (Electronic) Linking ISSN: 00219150 NLM ISO Abbreviation: Atherosclerosis Subsets: MEDLINE
    • Publication Information:
      Publication: Limerick : Elsevier
      Original Publication: Amsterdam, Elsevier.
    • Subject Terms:
      Biomarkers/*blood ; Carotid Artery Diseases/*blood ; Peptide Fragments/*blood ; Peripheral Arterial Disease/*blood ; Procollagen/*blood ; Retinal Diseases/*blood ; Transforming Growth Factor beta/*blood; Aged ; Ankle Brachial Index ; Brachial Artery/physiopathology ; Carotid Artery Diseases/diagnosis ; Carotid Artery Diseases/epidemiology ; Carotid Artery Diseases/physiopathology ; Carotid Intima-Media Thickness ; Cross-Sectional Studies ; Female ; Fibrosis ; Humans ; Incidence ; Male ; Peripheral Arterial Disease/diagnosis ; Peripheral Arterial Disease/epidemiology ; Peripheral Arterial Disease/physiopathology ; Predictive Value of Tests ; Prognosis ; Prospective Studies ; Retinal Diseases/diagnosis ; Retinal Diseases/epidemiology ; Retinal Diseases/physiopathology ; Risk Factors ; United States/epidemiology ; Vasodilation
    • Abstract:
      Objective: Fibrosis has been implicated in a number of pathological, organ-based conditions of the liver, kidney, heart, and lungs. The objective of this study was to determine whether biomarkers of fibrosis are associated with vascular disease in the large and/or small vessels.
      Methods: We evaluated the associations of two circulating biomarkers of fibrosis, transforming growth factor-β (TGF-β) and procollagen type III N-terminal propeptide (PIIINP), with incident peripheral artery disease (PAD) and subclinical macrovascular (carotid intima-media thickness, flow-mediated vasodilation, ankle-brachial index, retinal vein diameter), and microvascular (retinal artery diameter and retinopathy) disease among older adults in the Cardiovascular Health Study. We measured TGF-β and PIIINP from samples collected in 1996 and ascertained clinical PAD through 2011. Measurements of large and small vessels were collected between 1996 and 1998.
      Results: After adjustment for sociodemographic, clinical, and biochemical risk factors, TGF-β was associated with incident PAD (hazard ratio [HR] = 1.36 per doubling of TGF-β, 95% confidence interval [CI] = 1.04, 1.78) and retinal venular diameter (1.63 μm per doubling of TGF-β, CI = 0.23, 3.02). PIIINP was not associated with incident PAD, but was associated with carotid intima-media thickness (0.102 mm per doubling of PIIINP, CI = 0.029, 0.174) and impaired brachial artery reactivity (-0.20% change per doubling of PIIINP, CI = -0.39, -0.02). Neither TGF-β nor PIIINP were associated with retinal arteriolar diameter or retinopathy.
      Conclusions: Serum concentrations of fibrosis-related biomarkers were associated with several measures of large vessel disease, including incident PAD, but not with small vessel disease. Fibrosis may contribute to large vessel atherosclerosis in older adults.
      (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)
    • References:
      Diabetes Res Clin Pract. 1994 Apr;23(3):179-82. (PMID: 7924878)
      Arch Intern Med. 2006 Nov 27;166(21):2388-94. (PMID: 17130394)
      J Vasc Surg. 2008 Nov;48(5):1197-203. (PMID: 18692981)
      Kidney Int. 2004 Jan;65(1):63-74. (PMID: 14675037)
      J Mol Med (Berl). 1999 May;77(5):437-45. (PMID: 10426193)
      Transplantation. 1999 Aug 27;68(4):468-9. (PMID: 10480399)
      Stroke. 1996 Feb;27(2):224-31. (PMID: 8571414)
      Hepatology. 2000 Aug;32(2):247-55. (PMID: 10915731)
      N Engl J Med. 1999 Jan 7;340(1):14-22. (PMID: 9878640)
      Stroke. 2009 Dec;40(12):3695-9. (PMID: 19815829)
      Am J Epidemiol. 2014 Jun 1;179(11):1331-9. (PMID: 24771724)
      Mod Pathol. 1995 Jun;8(5):478-82. (PMID: 7675764)
      JAMA. 2002 Jul 3;288(1):67-74. (PMID: 12090864)
      Stroke. 1991 Sep;22(9):1155-63. (PMID: 1926258)
      Am J Physiol Lung Cell Mol Physiol. 2007 Jul;293(1):L151-61. (PMID: 17400601)
      Expert Rev Respir Med. 2011 Aug;5(4):473-81. (PMID: 21859266)
      Vasc Health Risk Manag. 2008;4(3):575-96. (PMID: 18827908)
      Nat Med. 1995 Jan;1(1):74-9. (PMID: 7584958)
      J Cardiovasc Risk. 2001 Oct;8(5):319-28. (PMID: 11702039)
      Mech Ageing Dev. 2001 Jul 31;122(10):1049-58. (PMID: 11389923)
      J Stroke Cerebrovasc Dis. 2008 Nov-Dec;17(6):412-7. (PMID: 18984437)
      J Clin Epidemiol. 1992 Jun;45(6):683-92. (PMID: 1607909)
      Am J Epidemiol. 1989 Jun;129(6):1110-9. (PMID: 2786328)
      Neurology. 2003 Sep 23;61(6):806-11. (PMID: 14504325)
      Circulation. 2007 May 8;115(18):2390-7. (PMID: 17452608)
      Am J Epidemiol. 2009 Dec 1;170(11):1323-32. (PMID: 19884126)
      Hypertension. 2010 Apr;55(4):953-60. (PMID: 20157054)
      Ophthalmology. 1999 Dec;106(12):2269-80. (PMID: 10599656)
      J Am Soc Nephrol. 2011 Jun;22(6):1144-51. (PMID: 21511828)
      Hypertension. 2008 Jan;51(1):119-26. (PMID: 17998474)
      Diabetes Care. 1996 Oct;19(10):1113-7. (PMID: 8886558)
      J Histochem Cytochem. 1996 Dec;44(12):1469-79. (PMID: 8985139)
      Neurology. 2006 Jun 27;66(12):1946-8. (PMID: 16801669)
      Stroke. 2006 Jan;37(1):82-6. (PMID: 16306463)
      Nat Med. 2012 Jul;18(7):1028-40. (PMID: 22772564)
      Invest Ophthalmol Vis Sci. 2004 Jul;45(7):2129-34. (PMID: 15223786)
      FASEB J. 2001 Jul;15(9):1619-21. (PMID: 11427505)
      Lancet Neurol. 2009 Jul;8(7):628-34. (PMID: 19481977)
      Cardiovasc Res. 2007 May 1;74(2):196-206. (PMID: 17376414)
      Arterioscler Thromb Vasc Biol. 2001 May;21(5):785-90. (PMID: 11348875)
      Arterioscler Thromb Vasc Biol. 2004 Mar;24(3):399-404. (PMID: 14699019)
      Invest Ophthalmol Vis Sci. 2006 Jan;47(1):86-92. (PMID: 16384948)
      Atherosclerosis. 2011 Feb;214(2):391-6. (PMID: 21167485)
      Ann Epidemiol. 1991 Feb;1(3):263-76. (PMID: 1669507)
      Am J Epidemiol. 2007 Jan 1;165(1):78-84. (PMID: 17041135)
      Aging Dis. 2011 Apr;2(2):158-173. (PMID: 21837283)
      Circulation. 1993 Sep;88(3):837-45. (PMID: 8353913)
      Int J Mol Med. 2005 Apr;15(4):603-10. (PMID: 15754021)
    • Grant Information:
      N01HC85084 United States HC NHLBI NIH HHS; U01 HL080295 United States HL NHLBI NIH HHS; HHSN268200800007C United States HL NHLBI NIH HHS; N01HC85085 United States HC NHLBI NIH HHS; N01 HC085085 United States HC NHLBI NIH HHS; N01HC55222 United States HL NHLBI NIH HHS; HL094555 United States HL NHLBI NIH HHS; F30 HL118775 United States HL NHLBI NIH HHS; R01 HL080295 United States HL NHLBI NIH HHS; N01HC85083 United States HL NHLBI NIH HHS; HL080295 United States HL NHLBI NIH HHS; R01 HL094555 United States HL NHLBI NIH HHS; N01HC85086 United States HL NHLBI NIH HHS; N01HC45133 United States HC NHLBI NIH HHS; HHSN268201200036C United States HL NHLBI NIH HHS; HL118775 United States HL NHLBI NIH HHS; N01 HC085084 United States HC NHLBI NIH HHS; N01HC85082 United States HL NHLBI NIH HHS; N01HC85079 United States HL NHLBI NIH HHS; R01 AG023629 United States AG NIA NIH HHS; N01HC35129 United States HC NHLBI NIH HHS; N01HC85080 United States HL NHLBI NIH HHS; AG023629 United States AG NIA NIH HHS; R56 AG023629 United States AG NIA NIH HHS; N01HC85081 United States HL NHLBI NIH HHS; N01 HC55222 United States HC NHLBI NIH HHS
    • Contributed Indexing:
      Keywords: Atherosclerosis; Fibrosis; Peripheral artery disease
    • Accession Number:
      0 (Biomarkers)
      0 (Peptide Fragments)
      0 (Procollagen)
      0 (Transforming Growth Factor beta)
      0 (procollagen Type III-N-terminal peptide)
    • Publication Date:
      Date Created: 20150301 Date Completed: 20151214 Latest Revision: 20240610
    • Publication Date:
      20240610
    • Accession Number:
      PMC4517825
    • Accession Number:
      10.1016/j.atherosclerosis.2015.02.020
    • Accession Number:
      25725316