[Efficacy and safety of sugammadex (Org 25969) in reversing deep neuromuscular block induced by rocuronium or vecuronium in Japanese patients].

Publisher: Nippon Masui Gakki Country of Publication: Japan NLM ID: 0413707 Publication Model: Print Cited Medium: Print ISSN: 0021-4892 (Print) Linking ISSN: 00214892 NLM ISO Abbreviation: Masui Subsets: MEDLINE

Publication: Tokyo : Nippon Masui Gakki
Original Publication: Tokyo.

Anesthesia Recovery Period* ; Anesthesia, General* ; Neuromuscular Blockade*; Androstanols/*antagonists & inhibitors ; Neuromuscular Nondepolarizing Agents/*antagonists & inhibitors ; Vecuronium Bromide/*antagonists & inhibitors ; gamma-Cyclodextrins/*pharmacology; Adult ; Androstanols/administration & dosage ; Asian People ; Dose-Response Relationship, Drug ; Female ; Humans ; Male ; Middle Aged ; Neuromuscular Nondepolarizing Agents/administration & dosage ; Rocuronium ; Sugammadex ; Vecuronium Bromide/administration & dosage ; gamma-Cyclodextrins/administration & dosage

Background: Efficacy and safety of sugammadex in reversing neuromuscular block induced by rocuronium or vecuronium were investgated in Japanese patients.
Methods: We studied 99 Japanese patients undergoing surgery requiring general anesthesia. Patients were allocated randomly to receive intubation dose of rocuronium or vecuronium. During surgery, patients received additional dose of rocuronium or vecuronium for maintenance of deep block. At 1-2 PTC, 0.5-8.0 mg . kg-1 of sugammadex was administered. The neuromuscular block was monitored with acceleromyography using TOF stimuli. Sevoflurane was administered to all treatment groups after intubation.
Results: For the rocuronium-induced neuromuscular block, the mean recovery time of the T4/T1 ratio to 0.9 decreased from 66.9 min in the sugammadex 0.5 mg kg-1 group to 1.3 min in the sugammadex 8.0 mg kg-1 group. For the vecuronium-induced neuromuscular block it decreased from 79.5 min in the sugammadex 0.5 mg . kg-1 group to 2.9 min in the sugammadex 8.0 mg . kg-1 group. No clinical evidence of recurarization or residual curarization was observed.
Conclusions: The efficacy and safety of sugammadex were confirmed in Japanese surgical patients for reversal from deep block.

0 (Androstanols)
0 (Neuromuscular Nondepolarizing Agents)
0 (gamma-Cyclodextrins)
361LPM2T56 (Sugammadex)
7E4PHP5N1D (Vecuronium Bromide)
WRE554RFEZ (Rocuronium)

Date Created: 20150220 Date Completed: 20150323 Latest Revision: 20221207

20231215

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