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Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance.
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- Additional Information
- Source:
Publisher: Elsevier Science Publishers Country of Publication: England NLM ID: 9200566 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3088 (Electronic) Linking ISSN: 09628924 NLM ISO Abbreviation: Trends Cell Biol Subsets: MEDLINE
- Publication Information:
Original Publication: Cambridge, UK : Elsevier Science Publishers, c1991-
- Subject Terms:
- Abstract:
Interactions between cancer cells and their surroundings can trigger essential signaling cues that determine cell fate and influence the evolution of the malignant phenotype. As the primary receptors involved in cell-matrix adhesion, integrins present on the surface of tumor and stromal cells have a profound impact on the ability to survive in specific locations, but in some cases, these receptors can also function in the absence of ligand binding to promote stemness and survival in the presence of environmental and therapeutic stresses. Understanding how integrin expression and function is regulated in this context will enable the development of new therapeutic approaches to sensitize tumors to therapy and suppress their metastatic phenotype.
(Copyright © 2014 Elsevier Ltd. All rights reserved.)
- References:
Nat Rev Cancer. 2010 Jan;10(1):9-22. (PMID: 20029421)
Cell Stem Cell. 2010 May 7;6(5):421-32. (PMID: 20452317)
Science. 2014 Jun 13;344(6189):1242281. (PMID: 24926024)
Dev Cell. 2014 Aug 11;30(3):295-308. (PMID: 25117682)
Oncogene. 2014 Aug 21;33(34):4286-95. (PMID: 24077284)
J Cell Sci. 2014 Sep 1;127(Pt 17):3641-8. (PMID: 25128561)
Mol Cancer. 2014;13:208. (PMID: 25200184)
Int J Cancer. 2015 Jun 1;136(11):2504-14. (PMID: 24771582)
Nat Rev Mol Cell Biol. 2010 Apr;11(4):288-300. (PMID: 20308986)
Curr Cancer Drug Targets. 2002 Mar;2(1):37-43. (PMID: 12188919)
J Cell Biol. 2003 Sep 1;162(5):933-43. (PMID: 12952943)
Nat Rev Mol Cell Biol. 2004 Oct;5(10):816-26. (PMID: 15459662)
Cell. 1996 May 31;85(5):683-93. (PMID: 8646777)
Nature. 2006 Jan 5;439(7072):84-8. (PMID: 16397499)
Nature. 2006 Feb 23;439(7079):993-7. (PMID: 16395311)
J Cell Biol. 2006 Nov 6;175(3):505-14. (PMID: 17088430)
Mol Cancer Ther. 2006 Dec;5(12):3122-9. (PMID: 17172415)
Nat Cell Biol. 2007 Feb;9(2):201-9. (PMID: 17187062)
Cancer Metastasis Rev. 2010 Jun;29(2):285-93. (PMID: 20393783)
Oncogene. 2010 Aug 26;29(34):4741-51. (PMID: 20531305)
Cell. 2011 Feb 18;144(4):577-89. (PMID: 21335239)
Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10544-9. (PMID: 21670270)
Nat Med. 2011 Jul;17(7):867-74. (PMID: 21706029)
Breast Cancer Res. 2011;13(4):R84. (PMID: 21884573)
Cancer Res. 2012 Jan 1;72(1):56-65. (PMID: 22094875)
Nature. 2012 Jan 5;481(7379):85-9. (PMID: 22158103)
Cancer Lett. 2012 Mar 28;316(2):157-67. (PMID: 22099877)
J Clin Invest. 2012 Apr;122(4):1529-40. (PMID: 22378044)
EMBO Mol Med. 2013 Apr;5(4):488-508. (PMID: 23436775)
J Clin Invest. 2013 Feb;123(2):682-99. (PMID: 23348745)
Int J Cancer. 2013 Jul 15;133(2):416-26. (PMID: 23338841)
Proc Natl Acad Sci U S A. 2013 May 28;110(22):9042-7. (PMID: 23671068)
Dev Cell. 2013 May 28;25(4):402-16. (PMID: 23685250)
Carcinogenesis. 2013 Jun;34(6):1370-81. (PMID: 23389289)
Int J Oncol. 2013 Aug;43(2):425-30. (PMID: 23708747)
Oncogene. 2012 Apr 5;31(14):1757-70. (PMID: 21860410)
Oncogene. 2012 May 24;31(21):2614-26. (PMID: 21996747)
Oncogene. 2012 May 31;31(22):2783-93. (PMID: 21963850)
Cell Stem Cell. 2012 Jun 14;10(6):717-28. (PMID: 22704512)
Cancer Discov. 2012 Aug;2(8):706-21. (PMID: 22609699)
Mol Cancer. 2012;11:36. (PMID: 22640878)
Cell Stem Cell. 2012 Oct 5;11(4):529-40. (PMID: 23040479)
Nat Commun. 2012;3:1122. (PMID: 23047680)
Cancer Cell. 2012 Nov 13;22(5):615-30. (PMID: 23153535)
Cell Adh Migr. 2012 Nov-Dec;6(6):554-60. (PMID: 23076131)
Nat Cell Biol. 2013 Apr;15(4):338-44. (PMID: 23548926)
Nat Cell Biol. 2013 Jul;15(7):721-3. (PMID: 23817234)
Cancer Cell. 2013 Jul 8;24(1):59-74. (PMID: 23845442)
Cell Stem Cell. 2013 Sep 5;13(3):300-13. (PMID: 23871604)
Cancer Res. 2013 Oct 15;73(20):6243-53. (PMID: 23872583)
J Natl Cancer Inst. 2013 Oct 16;105(20):1558-70. (PMID: 24092920)
Oncol Rep. 2014 Jan;31(1):262-72. (PMID: 24173498)
Lab Invest. 2014 Jan;94(1):41-51. (PMID: 24247563)
Pharmacol Ther. 2014 Feb;141(2):222-33. (PMID: 24140083)
Biochemistry. 2014 Feb 11;53(5):810-20. (PMID: 24467163)
Prostate. 2014 May;74(5):488-96. (PMID: 24375374)
Nat Rev Mol Cell Biol. 2014 Mar;15(3):178-96. (PMID: 24556840)
Nat Med. 2014 Apr;20(4):360-7. (PMID: 24633304)
Nat Med. 2014 Apr;20(4):350-9. (PMID: 24681597)
Nat Cell Biol. 2014 May;16(5):457-68. (PMID: 24747441)
Cell Rep. 2014 May 8;7(3):747-61. (PMID: 24767994)
Nat Cell Biol. 2008 Jun;10(6):716-22. (PMID: 18469806)
Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10290-5. (PMID: 19502425)
Nat Med. 2009 Oct;15(10):1163-9. (PMID: 19734908)
Genes Dev. 2009 Nov 15;23(22):2563-77. (PMID: 19933147)
Cell Tissue Res. 2010 Jan;339(1):269-80. (PMID: 19693543)
- Grant Information:
R01 CA045726 United States CA NCI NIH HHS; T32 CA121938 United States CA NCI NIH HHS
- Contributed Indexing:
Keywords: cancer; drug resistance; integrins; stemness
- Accession Number:
0 (Integrins)
- Publication Date:
Date Created: 20150110 Date Completed: 20151202 Latest Revision: 20220409
- Publication Date:
20231215
- Accession Number:
PMC4380531
- Accession Number:
10.1016/j.tcb.2014.12.006
- Accession Number:
25572304
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