Baculoviruses and nucleosome management.

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  • Author(s): Volkman LE;Volkman LE
  • Source:
    Virology [Virology] 2015 Feb; Vol. 476, pp. 257-263. Date of Electronic Publication: 2015 Jan 05.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Academic Press Country of Publication: United States NLM ID: 0110674 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0341 (Electronic) Linking ISSN: 00426822 NLM ISO Abbreviation: Virology Subsets: MEDLINE
    • Publication Information:
      Original Publication: New York, Academic Press.
    • Subject Terms:
      Baculoviridae/*genetics ; Insecta/*virology ; Nucleosomes/*virology; Animals ; Baculoviridae/physiology ; Genome, Viral ; Insect Proteins/genetics ; Insect Proteins/metabolism ; Insecta/genetics ; Insecta/metabolism ; Nucleosomes/genetics ; Nucleosomes/metabolism ; Virus Replication
    • Abstract:
      Negatively-supercoiled-ds DNA molecules, including the genomes of baculoviruses, spontaneously wrap around cores of histones to form nucleosomes when present within eukaryotic nuclei. Hence, nucleosome management should be essential for baculovirus genome replication and temporal regulation of transcription, but this has not been documented. Nucleosome mobilization is the dominion of ATP-dependent chromatin-remodeling complexes. SWI/SNF and INO80, two of the best-studied complexes, as well as chromatin modifier TIP60, all contain actin as a subunit. Retrospective analysis of results of AcMNPV time course experiments wherein actin polymerization was blocked by cytochalasin D drug treatment implicate actin-containing chromatin modifying complexes in decatenating baculovirus genomes, shutting down host transcription, and regulating late and very late phases of viral transcription. Moreover, virus-mediated nuclear localization of actin early during infection may contribute to nucleosome management.
      (Copyright © 2014 The Author. Published by Elsevier Inc. All rights reserved.)
    • Contributed Indexing:
      Keywords: AcMNPV; Actin; Actin-containing chromatin modification complexes; Autographa californica M nucleopolyhedrovirus; Baculovirus; Negatively-supercoiled ds DNA; Nucleosomes; SWI/SNF, INO80, TIP60; Topoisomerase 2; Viral chromatin
    • Accession Number:
      0 (Insect Proteins)
      0 (Nucleosomes)
    • Publication Date:
      Date Created: 20150109 Date Completed: 20150413 Latest Revision: 20180429
    • Publication Date:
      20221213
    • Accession Number:
      10.1016/j.virol.2014.12.022
    • Accession Number:
      25569454