[Human stem cells in the treatment of pancreatic and hepatic diseases].

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  • Additional Information
    • Transliterated Title:
      Ihmisen kantasolut haima- ja maksasairauksien hoidossa.
    • Source:
      Publisher: Laaeketieteellinen Aikakauskirja Duodecim Country of Publication: Finland NLM ID: 0373207 Publication Model: Print Cited Medium: Print ISSN: 0012-7183 (Print) Linking ISSN: 00127183 NLM ISO Abbreviation: Duodecim Subsets: MEDLINE
    • Publication Information:
      Publication: Helsinki : Laaeketieteellinen Aikakauskirja Duodecim
      Original Publication: Helsinki, Suomalainen Lääkäriseura Duodecim.
    • Subject Terms:
      Liver Diseases/*therapy ; Pancreatic Diseases/*therapy ; Stem Cell Transplantation/*methods; Cell Differentiation ; Chronic Disease ; Diabetes Mellitus/therapy ; Hepatocytes/cytology ; Humans ; Islets of Langerhans/cytology
    • Abstract:
      The pancreas and the liver are developmentally closely connected with each other.The development of stem cell technology has enabled the production of functional pancreatic endocrine cells and hepatocytes from pluripotent human stem cells. The differentiation of cells takes place by mimicking the events of developmental biology on a cell culture dish. The research is aiming at the development of cell replacement therapy for diabetes and hepatic insufficiency. Transplantations of islet cells have proven the possibilities of this strategy as a replacement of insulin therapy. Although there are promising initial clinical observations on hepatocyte transplantation, the limited growth capacity of these cells restricts the efficiency of the treatment.
    • Publication Date:
      Date Created: 20150107 Date Completed: 20150129 Latest Revision: 20150106
    • Publication Date:
      20240829
    • Accession Number:
      25558618