Hormonal and metabolic responses to endurance exercise in children with Prader-Willi syndrome and non-syndromic obesity.

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  • Additional Information
    • Source:
      Publisher: W.B. Saunders Country of Publication: United States NLM ID: 0375267 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8600 (Electronic) Linking ISSN: 00260495 NLM ISO Abbreviation: Metabolism Subsets: MEDLINE
    • Publication Information:
      Publication: Philadelphia, PA : W.B. Saunders
      Original Publication: New York, Grune & Stratton.
    • Subject Terms:
      Exercise Therapy* ; Physical Endurance*; Hormones/*metabolism ; Obesity/*metabolism ; Obesity/*rehabilitation ; Prader-Willi Syndrome/*metabolism ; Prader-Willi Syndrome/*rehabilitation; Bicycling ; Blood Glucose/metabolism ; Body Composition ; Body Weight ; Child ; Female ; Humans ; Male
    • Abstract:
      Objective: Excess adiposity affects endocrine and metabolic function at rest and during exercise. This study evaluated the endocrine and metabolic responses to exercise in syndromic (Prader-Willi syndrome) and non-syndromic pediatric obesity.
      Materials/methods: Eleven PWS (10.9±1.6 y, 45.4±9.5% body fat), 12 lean (9.4±1.2 y, 17.5±4.6% body fat), and 12 obese (9.2±1.2 y, 39.9±6.8% body fat) children completed ten two-minute cycling exercise bouts, separated by one-minute rest. Blood samples were obtained at rest pre-exercise (PRE), immediately post-exercise (IP), and 15, 30 and 60 minutes into recovery. Samples were analyzed for hormones and metabolites.
      Results: Growth hormone increased in response to exercise in lean and obese but not PWS (IP>PRE; IP: lean>obese). Epinephrine increased with exercise in lean (IP>PRE), while norepinephrine increased in lean and obese (IP>PRE) but not PWS; no differences were observed between lean and obese groups at IP. No other significant hormonal group interactions existed. Glucose, lactate, free fatty acid, glycerol and ketone responses were similar among groups.
      Conclusion: PWS children exhibited altered stress hormone responses to exercise. However, glucose-regulating hormones and metabolic responses to exercise appeared normal.
      (Copyright © 2015 Elsevier Inc. All rights reserved.)
    • Grant Information:
      Canada Canadian Institutes of Health Research
    • Contributed Indexing:
      Keywords: Adiposity; Endocrinology; Exercise physiology; Genetics
    • Accession Number:
      0 (Blood Glucose)
      0 (Hormones)
    • Publication Date:
      Date Created: 20141220 Date Completed: 20150330 Latest Revision: 20150130
    • Publication Date:
      20231215
    • Accession Number:
      10.1016/j.metabol.2014.11.011
    • Accession Number:
      25524794