Geographic differences in the associations between impaired glucose regulation and cardiovascular risk factors among young adults.

Publisher: Blackwell Science Country of Publication: England NLM ID: 8500858 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-5491 (Electronic) Linking ISSN: 07423071 NLM ISO Abbreviation: Diabet Med Subsets: MEDLINE

Publication: Oxford : Blackwell Science
Original Publication: Chichester [Sussex, England] ; New York : Wiley, [c1984-

Diabetes Mellitus, Type 2/*epidemiology ; Diabetic Angiopathies/*epidemiology ; Glucose Intolerance/*epidemiology; Adult ; Africa, Eastern/epidemiology ; Asia/epidemiology ; Australia/epidemiology ; Cross-Sectional Studies ; Female ; Greenland/epidemiology ; Humans ; Male ; Prevalence ; Residence Characteristics ; Risk Factors ; Young Adult

Aims: To assess geographic differences in the association between BMI, blood pressure and lipid levels with impaired glucose regulation among young adults from various geographical regions.
Methods: This was a cross-sectional study including data from 6987 participants aged ≤ 30 years from India, Singapore, Australia, Greenland, Kenya and Tanzania. Impaired glucose regulation was determined by the 75-g oral glucose tolerance test. For each geographical region, BMI, blood pressure and lipids were examined and compared between participants with normal glucose tolerance and those with impaired glucose regulation. Multiple logistic regression models were used to assess the association between risk factors and impaired glucose regulation.
Results: Indian and East African people had a higher prevalence of impaired glucose regulation compared with participants from other regions, despite their lower BMI. Compared with the other regions, blood pressure was lower among Indian and Singaporean people but higher in those from Greenland. Greenlanders had the highest, while Indian and East-African people, had the lowest level of HDL cholesterol. BMI was positively associated with impaired glucose regulation in all regions, and there were no statistically significant geographic differences. In the Indian, Singaporean and Australian participants, there was a positive association between blood pressure and impaired glucose regulation. Triglycerides were positively associated with and HDL cholesterol had no association with impaired glucose regulation in all geographical regions.
Conclusions: Higher BMI and triglyceride levels were positively associated with prevalent impaired glucose regulation in all geographical regions. There were geographic differences in the association between impaired glucose regulation and blood pressure and lipids, probably reflecting environmental and genetic factors.
(© 2014 The Authors. Diabetic Medicine © 2014 Diabetes UK.)

586623 United Kingdom Medical Research Council

Date Created: 20141220 Date Completed: 20151130 Latest Revision: 20150316

20240628

10.1111/dme.12674

25523878