Association of polymorphisms in drug transporter genes (SLCO1B1 and SLC10A1) and anti-tuberculosis drug-induced hepatotoxicity in a Chinese cohort.

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  • Additional Information
    • Source:
      Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 100971555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-281X (Electronic) Linking ISSN: 14729792 NLM ISO Abbreviation: Tuberculosis (Edinb) Subsets: MEDLINE
    • Publication Information:
      Original Publication: Edinburgh, New York : Churchill Livingstone, c2001-
    • Subject Terms:
      Antitubercular Agents/*adverse effects ; Chemical and Drug Induced Liver Injury/*genetics ; Organic Anion Transporters/*genetics ; Organic Anion Transporters, Sodium-Dependent/*genetics ; Polymorphism, Single Nucleotide/*genetics ; Symporters/*genetics ; Tuberculosis, Pulmonary/*genetics; Adult ; China/ethnology ; Female ; Genotyping Techniques ; Haplotypes/genetics ; Humans ; Linkage Disequilibrium/genetics ; Liver-Specific Organic Anion Transporter 1 ; Male ; Tuberculosis, Pulmonary/drug therapy ; Tuberculosis, Pulmonary/ethnology
    • Abstract:
      This study investigated the association between genetic variants in two hepatic uptake transporter genes (SLCO1B1 and SLC10A1) and the risk of anti-tuberculosis drug-induced hepatotoxicity (ATDH) in a Chinese cohort. The frequencies and distributions of single nucleotide polymorphisms (SNPs) and haplotypes of these genes were compared among 89 incident ATDH cases and 356 matched ATDH-free controls using a multivariate conditional logistic regression analysis. After correction for potential confounding factors, significant differences were found in polymorphism of rs4149014 under an addictive model (P = 0.008) and a recessive model (P = 0.016). The result of haplotype analysis suggested that patients carrying at least one SLCO1B1*15 haplotype had a higher risk of ATDH (odds ratio (OR) = 1.74, 95% confidence intervals (CI): 1.04-2.90, P = 0.034) in comparison with those carrying SLCO1B1*1a or SLCO1B1*1b haplotypes. These findings indicate that genetic variants of SLCO1B1 are associated with the development of ATDH in Chinese population.
      (Copyright © 2014 Elsevier Ltd. All rights reserved.)
    • Contributed Indexing:
      Keywords: Anti-tuberculosis drug; Drug transporter; Hepatotoxicity
    • Accession Number:
      0 (Antitubercular Agents)
      0 (Liver-Specific Organic Anion Transporter 1)
      0 (Organic Anion Transporters)
      0 (Organic Anion Transporters, Sodium-Dependent)
      0 (SLCO1B1 protein, human)
      0 (Symporters)
      145420-23-1 (sodium-bile acid cotransporter)
    • Publication Date:
      Date Created: 20141216 Date Completed: 20150818 Latest Revision: 20181202
    • Publication Date:
      20221213
    • Accession Number:
      10.1016/j.tube.2014.11.004
    • Accession Number:
      25498879