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[Neuroprotective effect of neuroglutam under conditions of activated free radical oxidation].
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- Additional Information
- Source:
Publisher: Izd-vo Meditsina Country of Publication: Russia (Federation) NLM ID: 9215981 Publication Model: Print Cited Medium: Print ISSN: 0869-2092 (Print) Linking ISSN: 08692092 NLM ISO Abbreviation: Eksp Klin Farmakol Subsets: MEDLINE
- Publication Information:
Original Publication: Moskva : Izd-vo Meditsina
- Subject Terms:
- Abstract:
The neuroprotective properties of the novel glutamic acid derivative neiroglutam have been studied in vitro and in vivo. Neiroglutam demonstrated the protective action on 6-OH-dopamine neurotoxicity model in vitro, where free radical oxidation is a basic part of pathogenesis. In control rats, focal brain ischemia caused significant increase in thiobarbituric acid reactive species (TBARS) level and decrease in superoxide dismutase (SOD) enzyme activity. In two-year-old rats, preventive administration of the neiroglutam caused a significant reduction in the TBARS plasma concentration (34.5%, p < 0.05), increased SOD activity, and increased the time of acid-induced hemolysis of erythrocytes (40%, p < 0.05).
- Accession Number:
0 (Free Radicals)
0 (Neuroprotective Agents)
0 (Thiobarbituric Acid Reactive Substances)
3KX376GY7L (Glutamic Acid)
8HW4YBZ748 (Oxidopamine)
EC 1.15.1.1 (Superoxide Dismutase)
- Publication Date:
Date Created: 20141023 Date Completed: 20141104 Latest Revision: 20141022
- Publication Date:
20240829
- Accession Number:
25335385
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