Efficacy of fenbendazole and levamisole treatments in captive Houston toads (Bufo [Anaxyrus] houstonensis).

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  • Author(s): Bianchi CM; Johnson CB; Howard LL; Crump P
  • Source:
    Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians [J Zoo Wildl Med] 2014 Sep; Vol. 45 (3), pp. 564-8.
  • Publication Type:
    Clinical Trial; Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Association Of Zoo Veterinarians Country of Publication: United States NLM ID: 8915208 Publication Model: Print Cited Medium: Print ISSN: 1042-7260 (Print) Linking ISSN: 10427260 NLM ISO Abbreviation: J Zoo Wildl Med Subsets: MEDLINE
    • Publication Information:
      Publication: Lawrence Ks : American Association Of Zoo Veterinarians
      Original Publication: Lawrence, Kan. : The Association, [1989-
    • Subject Terms:
      Antinematodal Agents/*therapeutic use ; Fenbendazole/*therapeutic use ; Levamisole/*therapeutic use ; Nematode Infections/*veterinary; Animal Husbandry ; Animals ; Bufonidae ; Feces/parasitology ; Nematode Infections/drug therapy
    • Abstract:
      Effective disease monitoring and prevention is critical to the success of captive amphibian care. Nematodes, including the genera Rhabdias and Strongyloides, are known to contribute to mortality in captive amphibians and have been identified in the Houston Zoo's endangered Houston toad (Bufo [Anaxyrus] houstonensis) captive assurance colony. Five years of fecal data for the toad colony were compiled and analyzed in order to investigate the efficacy of two anthelminthic medications, fenbendazole (FBZ) and levamisole (LMS), which were used to control nematode infections. Both FBZ (dusted onto food items) and topical LMS (6.5 to 13.5 mg/kg) significantly reduced the number of nematode eggs, larvae, and adults observed by fecal parasitologic examination. There were no significant differences between treatments, and egg reappearance periods were difficult to compare as a result of low sample size. No adverse effects from either anthelminthic treatment were observed. Both topical LMS and oral FBZ appear to be safe and efficacious treatments for the reduction of the internal nematode burden in captive Houston toads.
    • Accession Number:
      0 (Antinematodal Agents)
      2880D3468G (Levamisole)
      621BVT9M36 (Fenbendazole)
    • Publication Date:
      Date Created: 20141016 Date Completed: 20141107 Latest Revision: 20141015
    • Publication Date:
      20231215
    • Accession Number:
      10.1638/2013-0250R.1
    • Accession Number:
      25314823