Bone morphogenetic proteins: a powerful osteoinductive compound with non-negligible side effects and limitations.

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  • Author(s): Oryan A;Oryan A; Alidadi S; Moshiri A; Bigham-Sadegh A
  • Source:
    BioFactors (Oxford, England) [Biofactors] 2014 Sep-Oct; Vol. 40 (5), pp. 459-81. Date of Electronic Publication: 2014 Oct 04.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Ios Press Country of Publication: Netherlands NLM ID: 8807441 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8081 (Electronic) Linking ISSN: 09516433 NLM ISO Abbreviation: Biofactors Subsets: MEDLINE
    • Publication Information:
      Publication: Amsterdam : Ios Press
      Original Publication: Oxford ; Washington, DC : Published for the International Union of Biochemistry by IRL Press, [c1988-
    • Subject Terms:
      Bone Density Conservation Agents/*therapeutic use ; Bone Morphogenetic Proteins/*therapeutic use ; Bone Regeneration/*drug effects; Animals ; Bone Density Conservation Agents/pharmacology ; Bone Diseases/drug therapy ; Bone Morphogenetic Proteins/pharmacology ; Fractures, Bone/drug therapy ; Humans ; Signal Transduction
    • Abstract:
      Healing and regeneration of large bone defects leading to non-unions is a great concern in orthopedic surgery. Since auto- and allografts have limitations, bone tissue engineering and regenerative medicine (TERM) has attempted to solve this issue. In TERM, healing promotive factors are necessary to regulate the several important events during healing. An ideal treatment strategy should provide osteoconduction, osteoinduction, osteogenesis, and osteointegration of the graft or biomaterials within the healing bone. Since many materials have osteoconductive properties, only a few biomaterials have osteoinductive properties which are important for osteogenesis and osteointegration. Bone morphogenetic proteins (BMPs) are potent inductors of the osteogenic and angiogenic activities during bone repair. The BMPs can regulate the production and activity of some growth factors which are necessary for the osteogenesis. Since the introduction of BMP, it has added a valuable tool to the surgeon's possibilities and is most commonly used in bone defects. Despite significant evidences suggesting their potential benefit on bone healing, there are some evidences showing their side effects such as ectopic bone formation, osteolysis and problems related to cost effectiveness. Bone tissue engineering may create a local environment, using the delivery systems, which enables BMPs to carry out their activities and to lower cost and complication rate associated with BMPs. This review represented the most important concepts and evidences regarding the role of BMPs on bone healing and regeneration from basic to clinical application. The major advantages and disadvantages of such biologic compounds together with the BMPs substitutes are also discussed.
      (© 2014 International Union of Biochemistry and Molecular Biology.)
    • Contributed Indexing:
      Keywords: BMPs substitutes; bone healing; bone morphogenetic protein; bone tissue engineering and regenerative medicine; delivery system
    • Accession Number:
      0 (Bone Density Conservation Agents)
      0 (Bone Morphogenetic Proteins)
    • Publication Date:
      Date Created: 20141007 Date Completed: 20150706 Latest Revision: 20141029
    • Publication Date:
      20231215
    • Accession Number:
      10.1002/biof.1177
    • Accession Number:
      25283434