Radiotherapy combined with daily escitalopram in patients with painful bone metastasis: clinical evaluation and quality of life measurements.

Publisher: BAKIS Productions LTD Country of Publication: Cyprus NLM ID: 100883428 Publication Model: Print Cited Medium: Print ISSN: 1107-0625 (Print) Linking ISSN: 11070625 NLM ISO Abbreviation: J BUON Subsets: MEDLINE

Publication: 2021- : Nicosia : BAKIS Productions LTD
Original Publication: Athens : Zerbinis Medical Publications

Quality of Life*; Bone Neoplasms/*secondary ; Bone Neoplasms/*therapy ; Citalopram/*therapeutic use ; Neuralgia/*therapy ; Radiotherapy, Conformal/*methods; Aged ; Aged, 80 and over ; Bone Neoplasms/psychology ; Combined Modality Therapy ; Female ; Humans ; Male ; Middle Aged

Purpose: To prospectively assess the efficacy of the selective serotonin inhibitor escitalopram on painful bone metastases, in combination with external beam irradiation.
Methods: Forty-three patients with cancer metastatic to bone and suffering from depression were treated with 3 Dimensional Conformal Radiotherapy (3DCRT) (30 Gy; 3 Gy/fraction, 5 days/week) combined with escitalopram (20 mg/day). Pain relief was evaluated with Wong/Baker Faces Pain Scale. The patients reported outcome using a RTOG-EORTC quality-of-life self-questionnaire (QLQ-C30 v3.0) and the status of depression according to Hamilton Scale (HAM-17). The assessment was performed at baseline and 6-8 weeks after radiotherapy.
Results: Patients treated with radiotherapy and escitalopram tended to show a good response to pain and improvement of their quality of life.
Conclusions: Though our data concerned a rather small number of patients, addition of escitalopram to 3DCRT accomplished a high clinical benefit rate on neuropathic pain from bone metastasis.

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Date Created: 20140928 Date Completed: 20141121 Latest Revision: 20140928

20221213

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