Posterior reversible encephalopathy syndrome (PRES) as a complication of immunosuppressive therapy in renal transplantation in children.

Publisher: Drustvo Ljekara Bosne I Hercegovine Country of Publication: Bosnia and Herzegovina NLM ID: 0400722 Publication Model: Print Cited Medium: Print Linking ISSN: 0350199X NLM ISO Abbreviation: Med Arh Subsets: MEDLINE

Original Publication: Sarajevo : Drustvo Ljekara Bosne I Hercegovine

Immunosuppressive Agents/*adverse effects ; Posterior Leukoencephalopathy Syndrome/*chemically induced ; Tacrolimus/*adverse effects; Adolescent ; Brain/pathology ; Female ; Humans ; Kidney Transplantation ; Magnetic Resonance Imaging ; Posterior Leukoencephalopathy Syndrome/pathology

Although kidney transplantation is by far the best method of renal replacement therapy, organ receiver is still not spared of eventual toxic consequences of drugs that are in charge of keeping the transplanted kidney functional. Both calcineurin inhibitors, of which tacrolimus more often, occasionally lead to neurotoxic side effects, mostly mild and reversible and dose-dependent in nature, but they can also be very severe or even fatal. It is very important to be aware of possible neurotoxic effects, to confirm them radiologically, and to prevent or reduce drug effects on nervous system. Sometimes the reduction of dose or substitution with another drug with similar mechanism effect is sufficient to terminate the neurotoxic effects of the drug and still not jeopardize the function of transplanted organ.

0 (Immunosuppressive Agents)
WM0HAQ4WNM (Tacrolimus)

Date Created: 20140909 Date Completed: 20141020 Latest Revision: 20150901

20231215

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