Hyaluronan, a truly "youthful" polysaccharide. Its medical applications.

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  • Author(s): Robert L;Robert L
  • Source:
    Pathologie-biologie [Pathol Biol (Paris)] 2015 Feb; Vol. 63 (1), pp. 32-4. Date of Electronic Publication: 2014 Aug 31.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: France NLM ID: 0265365 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3114 (Electronic) Linking ISSN: 03698114 NLM ISO Abbreviation: Pathol Biol (Paris) Subsets: MEDLINE
    • Publication Information:
      Publication: 2000- : Paris : Elsevier
      Original Publication: Paris, Expansion scientifique française.
    • Subject Terms:
      Hyaluronic Acid/*physiology ; Hyaluronic Acid/*therapeutic use; Aging/drug effects ; Aging/physiology ; Animals ; Humans ; Hyaluronic Acid/administration & dosage ; Injections, Intra-Articular ; Osteoarthritis/drug therapy ; Viscosupplementation/methods ; Viscosupplements/therapeutic use
    • Abstract:
      Hyaluronan (hyaluronic acid, HA) is a ubiquitous linear polysaccharide endowed with some exceptional physicochemical properties such as strong hydration and viscoelasticity that depend on the size of the molecule. It plays a variety of important physiological roles in tissue hydration and mechanical protection, for example in the umbilical cord, skin and most other tissues. Since its large scale preparation and the invention by E.A. Balazs of the preparation of its non-inflammatory fraction (NIF-NaHA), there have been several important medical and cosmetic applications, most notably of viscosurgery for eye operation, intra-articular injections for osteoarthritis and also for wrinkle filling on the face, as well as for drug administration. Its concentration in tissues is decreasing with age, source of loss of function and structure of tissues. The purpose of this review is to present a succinct overview of the essential properties of hyaluronan and its medical and esthetic applications.
      (Copyright © 2014 Elsevier Masson SAS. All rights reserved.)
    • Contributed Indexing:
      Keywords: Acide hyaluronique; Esthetic medicine; Hyaluronan; Hyaluronane; Hyaluronic acid; Hydratation; Hydration; Médecine esthétique; Osteoarthritis; Ostéoarthrite; Viscochirurgie; Viscoelasticity; Viscosupplementation; Viscosupplémentation; Viscosurgery; Viscoélasticité
    • Accession Number:
      0 (Viscosupplements)
      9004-61-9 (Hyaluronic Acid)
    • Publication Date:
      Date Created: 20140904 Date Completed: 20160829 Latest Revision: 20150209
    • Publication Date:
      20221213
    • Accession Number:
      10.1016/j.patbio.2014.05.019
    • Accession Number:
      25182691