Involvement of aquaporins in a mouse model of rotavirus diarrhea.

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  • Author(s): Cao M;Cao M; Yang M; Ou Z; Li D; Geng L; Chen P; Chen H; Gong S
  • Source:
    Virologica Sinica [Virol Sin] 2014 Aug; Vol. 29 (4), pp. 211-7. Date of Electronic Publication: 2014 Jul 30.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier B.V. on behalf of KeAi Communications Co. Ltd Country of Publication: Netherlands NLM ID: 101514185 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1995-820X (Electronic) Linking ISSN: 1995820X NLM ISO Abbreviation: Virol Sin Subsets: MEDLINE
    • Publication Information:
      Publication: 2022- : [Amsterdam, Netherlands] : Elsevier B.V. on behalf of KeAi Communications Co. Ltd.
      Original Publication: Beijing : Science Press
    • Subject Terms:
      Aquaporin 1/*metabolism ; Aquaporin 4/*metabolism ; Aquaporins/*metabolism ; Diarrhea/*metabolism ; Rotavirus/*physiology ; Rotavirus Infections/*metabolism; Animals ; Aquaporin 1/genetics ; Aquaporin 3/genetics ; Aquaporin 3/metabolism ; Aquaporin 4/genetics ; Aquaporins/genetics ; Colon/metabolism ; Diarrhea/genetics ; Diarrhea/virology ; Disease Models, Animal ; Down-Regulation ; Humans ; Mice ; Rotavirus Infections/genetics
    • Abstract:
      Rotavirus diarrhea is a major worldwide cause of infantile gastroenteritis; however, the mechanism responsible for intestinal fluid loss remains unclear. Water transfer across the intestinal epithelial membrane seems to occur because of aquaporins (AQPs). Accumulating evidence indicates that alterations in AQPs may play an important role in pathogenesis. Here, we focus on changes in AQPs in a mouse model of rotavirus diarrhea. In the present study, 32 of 35 mice developed diarrhea and mild dehydration within 24 hours after infection with rotavirus strain SA11. Intestinal epithelial cells demonstrated cytoplasmic vacuolation, malaligned villi, and atrophy. AQP1 expression was significantly attenuated in the ileum and colon in comparison with controls; likewise, AQP4 and -8 protein expression were significantly decreased in the colon of rotavirus diarrhea-infected mice. In contrast, AQP3 protein expression was significantly increased in the colon of rotavirus-infected mice in comparison with controls. These results indicate that rotavirus diarrhea is associated with the downregulation of AQP1, -4, and -8 expression. Therefore, AQPs play an important role in rotavirus diarrhea.
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    • Accession Number:
      0 (Aqp1 protein, mouse)
      0 (Aqp3 protein, mouse)
      0 (Aqp4 protein, mouse)
      0 (Aquaporin 4)
      0 (Aquaporins)
      0 (aquaporin 8)
      146410-94-8 (Aquaporin 1)
      158801-98-0 (Aquaporin 3)
    • Publication Date:
      Date Created: 20140828 Date Completed: 20150512 Latest Revision: 20211021
    • Publication Date:
      20221213
    • Accession Number:
      PMC8206414
    • Accession Number:
      10.1007/s12250-014-3469-z
    • Accession Number:
      25160756