Stem cell therapies in patients with single ventricle physiology.

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  • Author(s): Tarui S;Tarui S; Sano S; Sano S; Oh H; Oh H
  • Source:
    Methodist DeBakey cardiovascular journal [Methodist Debakey Cardiovasc J] 2014 Apr-Jun; Vol. 10 (2), pp. 77-81.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Methodist DeBakey Heart & Vascular Center Country of Publication: United States NLM ID: 101508600 Publication Model: Print Cited Medium: Internet ISSN: 1947-6108 (Electronic) Linking ISSN: 19476108 NLM ISO Abbreviation: Methodist Debakey Cardiovasc J Subsets: MEDLINE
    • Publication Information:
      Original Publication: Houston, TX : Methodist DeBakey Heart & Vascular Center
    • Subject Terms:
      Regeneration* ; Stem Cell Transplantation* ; Ventricular Function, Left*; Heart Ventricles/*surgery ; Hypoplastic Left Heart Syndrome/*surgery ; Regenerative Medicine/*methods; Animals ; Heart Ventricles/abnormalities ; Heart Ventricles/physiopathology ; Humans ; Hypoplastic Left Heart Syndrome/diagnosis ; Hypoplastic Left Heart Syndrome/physiopathology ; Recovery of Function ; Treatment Outcome
    • Abstract:
      Single ventricle physiology, especially hypoplastic left heart syndrome, is one of the most high-risk lesions in children with congenital heart disease, and the ensuing heart failure remains as a major problem related to adverse outcomes in these patients. The field of stem cell therapy for heart failure has shown striking advances during the past 10 years, and many clinical trials using stem cell technologies have been conducted in adults, which suggest that stem cell therapy is associated with long-term improvement in cardiac function. Cardiac progenitor cells have recently been discovered, and their strong regenerative ability has been demonstrated in several studies. Although no large clinical trials have been performed in the field of congenital heart disease, recent investigations indicate that stem cell therapy may hold great potential to treat children with cardiac defects.
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    • Contributed Indexing:
      Keywords: cardiac progenitors; cell therapy; congenital heart disease; hypoplastic left heart syndrome; single ventricle physiology
    • Publication Date:
      Date Created: 20140813 Date Completed: 20151026 Latest Revision: 20211021
    • Publication Date:
      20221213
    • Accession Number:
      PMC4117324
    • Accession Number:
      10.14797/mdcj-10-2-77
    • Accession Number:
      25114758