Reappraising the long-term course and outcome of psychotic disorders: the AESOP-10 study.

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  • Additional Information
    • Source:
      Publisher: Cambridge University Press Country of Publication: England NLM ID: 1254142 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-8978 (Electronic) Linking ISSN: 00332917 NLM ISO Abbreviation: Psychol Med Subsets: MEDLINE
    • Publication Information:
      Publication: London : Cambridge University Press
      Original Publication: London, British Medical Assn.
    • Subject Terms:
      Disease Progression*; Hospitalization/*statistics & numerical data ; Psychotic Disorders/*epidemiology; Adult ; England/epidemiology ; Female ; Follow-Up Studies ; Humans ; Incidence ; London/epidemiology ; Male ; Middle Aged ; Psychotic Disorders/mortality ; Sex Factors
    • Abstract:
      Background: Studies of the long-term course and outcome of psychoses tend to focus on cohorts of prevalent cases. Such studies bias samples towards those with poor outcomes, which may distort our understanding of prognosis. Long-term follow-up studies of epidemiologically robust first-episode samples are rare.
      Method: AESOP-10 is a 10-year follow-up study of 557 individuals with a first episode of psychosis initially identified in two areas in the UK (South East London and Nottingham). Detailed information was collated on course and outcome in three domains (clinical, social and service use) from case records, informants and follow-up interviews.
      Results: At follow-up, of 532 incident cases identified, at baseline 37 (7%) had died, 29 (6%) had emigrated and eight (2%) were excluded. Of the remaining 458, 412 (90%) were traced and some information on follow-up was collated for 387 (85%). Most cases (265, 77%) experienced at least one period of sustained remission; at follow-up, 141 (46%) had been symptom free for at least 2 years. A majority (208, 72%) of cases had been employed for less than 25% of the follow-up period. The median number of hospital admissions, including at first presentation, was 2 [interquartile range (IQR) 1-4]; a majority (299, 88%) were admitted a least once and a minority (21, 6%) had 10 or more admissions. Overall, outcomes were worse for those with a non-affective diagnosis, for men and for those from South East London.
      Conclusions: Sustained periods of symptom remission are usual following first presentation to mental health services for psychosis, including for those with a non-affective disorder; almost half recover.
    • Comments:
      Erratum in: Psychol Med. 2014 Oct;44(13):2727.
      Comment in: Psychol Med. 2014 Oct;44(13):2705-11. (PMID: 25066328)
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    • Grant Information:
      G0600972 United Kingdom MRC_ Medical Research Council; G106/1148 United Kingdom MRC_ Medical Research Council; PDF-2011-04-065 United Kingdom DH_ Department of Health; G0500817 United Kingdom MRC_ Medical Research Council
    • Contributed Indexing:
      Indexing Agency: NLM Local ID #: EMS57782.
    • Publication Date:
      Date Created: 20140729 Date Completed: 20151026 Latest Revision: 20220321
    • Publication Date:
      20231215
    • Accession Number:
      PMC4134320
    • Accession Number:
      10.1017/S0033291714000282
    • Accession Number:
      25066181