Elaeodendron orientale as a source of cytotoxic cardenolides.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: England NLM ID: 0151434 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3700 (Electronic) Linking ISSN: 00319422 NLM ISO Abbreviation: Phytochemistry Subsets: MEDLINE
    • Publication Information:
      Publication: 2003- : London : Elsevier
      Original Publication: 1961-2003: Oxford : Pergamon Press.
    • Subject Terms:
      Antineoplastic Agents, Phytogenic/*isolation & purification ; Antineoplastic Agents, Phytogenic/*pharmacology ; Cardenolides/*isolation & purification ; Cardenolides/*pharmacology ; Celastraceae/*chemistry; Animals ; Antineoplastic Agents, Phytogenic/chemistry ; Cardenolides/chemistry ; Chlorocebus aethiops ; Digoxin/pharmacology ; HL-60 Cells ; HeLa Cells ; Humans ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Plant Leaves/chemistry ; Vero Cells ; X-Ray Diffraction
    • Abstract:
      In the present study, we report six cardiac glycosides (1-6) along with four known ones (7-10) isolated from the leaves and fruits of Elaeodendron orientale. Their stereostructures were elucidated on the basis of spectroscopic analysis, including 1D and 2D NMR, and the absolute configuration of 1 was determined by X-ray diffraction analysis. The compounds were evaluated for growth inhibitory activity against a panel of human cancer cell lines, HeLa, A-549, MCF-7 and HL-60, and normal Vero cells. Four compounds from this series (5 and 7-9, IC50 values ranging from 0.01 to 0.07μM) exhibited cytotoxicity against three of the cancer cell lines assayed that was similar to or higher than the well-known therapies digoxin and digitoxigenin. Taking into account the narrow safety range of cardiac glycosides used in clinic, this series shows a selectivity index higher than 3 for three of the cancer cell lines assayed, increasing their interest for further study.
      (Copyright © 2014 Elsevier Ltd. All rights reserved.)
    • Contributed Indexing:
      Keywords: Antiproliferative; Cardenolides; Celastraceae; Elaeodendron orientale; Human cancer cell lines
    • Accession Number:
      0 (Antineoplastic Agents, Phytogenic)
      0 (Cardenolides)
      73K4184T59 (Digoxin)
    • Publication Date:
      Date Created: 20140712 Date Completed: 20150204 Latest Revision: 20191210
    • Publication Date:
      20221213
    • Accession Number:
      10.1016/j.phytochem.2014.06.009
    • Accession Number:
      25014657