[Application of a method of material-energy balance for controlling the process of microbiological synthesis of riboxin].

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  • Author(s): Toĭtman AI; Malkov MA; Kil'fin GI
  • Source:
    Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] [Antibiot Khimioter] 1989 Feb; Vol. 34 (2), pp. 98-101.
  • Publication Type:
    English Abstract; Journal Article
  • Language:
    Russian
  • Additional Information
    • Transliterated Title:
      Primenenie metoda material'no-énergeticheskogo balansa dlia upravleniia protsessom mikrobiologicheskogo sinteza riboksina.
    • Source:
      Publisher: Izdatelstvo Meditsina Country of Publication: Russia (Federation) NLM ID: 8803688 Publication Model: Print Cited Medium: Print ISSN: 0235-2990 (Print) Linking ISSN: 02352990 NLM ISO Abbreviation: Antibiot Khimioter Subsets: MEDLINE
    • Publication Information:
      Publication: Moskva : Izdatelstvo Meditsina
      Original Publication: Moskva : Meditsina, c1988-
    • Subject Terms:
      Energy Metabolism*; Bacillus subtilis/*metabolism ; Inosine Diphosphate/*biosynthesis ; Inosine Nucleotides/*biosynthesis; Bacteriological Techniques
    • Abstract:
      Possible control of riboxin biosynthesis on the basis of the information provided with the method of material-energy balance was studied. Correspondence of the cultivation conditions to the directed biosynthesis was established by comparing the experimental values of the respiration coefficient delta CO2/delta O2, the coefficient of constructive and energy metabolism conjugate Cc/e and the ratio of the consumed amounts of glucose and ammonium nitrogen delta S/delta NH4+ with the theoretical values of these parameters. The control principle included changing of the process operation parameters for providing cultivation conditions approximating the experimental values of Cc/e, delta CO2/delta O2 and delta S/delta NH4+ to their theoretical values. It was shown possible to control directed aerobic growth of the culture by changing the aeration conditions. A decrease in the initial aeration rate promoted more rapid transition of the microbial population to the exponential growth phase and provided for a certain period cultivation conditions corresponding to the conditions of conjugate metabolism. It was found that the respiration coefficient could be used not only as a parameter reflecting one of the forms of the cell physiological activity manifestation but also as an optimization criterion in development of a controlled cultivation process.
    • Accession Number:
      0 (Inosine Nucleotides)
      86-04-4 (Inosine Diphosphate)
    • Publication Date:
      Date Created: 19890201 Date Completed: 19890710 Latest Revision: 20161020
    • Publication Date:
      20221213
    • Accession Number:
      2499287