[Involvement and plasticity of brainstem cholinergic neurons in cocaine-induced addiction].

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  • Author(s): Kaneda K; Shinohara F; Kurosawa R; Taoka N; Ide S; Minami M
  • Source:
    Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence [Nihon Arukoru Yakubutsu Igakkai Zasshi] 2014 Apr; Vol. 49 (2), pp. 92-103.
  • Publication Type:
    English Abstract; Journal Article; Review
  • Language:
    Japanese
  • Additional Information
    • Source:
      Publisher: Japanese Medical Society Of Alcohol And Drug Studies Country of Publication: Japan NLM ID: 9612304 Publication Model: Print Cited Medium: Print ISSN: 1341-8963 (Print) Linking ISSN: 13418963 NLM ISO Abbreviation: Nihon Arukoru Yakubutsu Igakkai Zasshi Subsets: MEDLINE
    • Publication Information:
      Publication: Kyoto : Japanese Medical Society Of Alcohol And Drug Studies
      Original Publication: Kyōto : Japanese Medical Society of Alcohol & Drug Studies, Heisei 8 [1996]-
    • Subject Terms:
      Cocaine-Related Disorders*/physiopathology; Brain Stem/*drug effects ; Cholinergic Neurons/*drug effects ; Cocaine/*pharmacology ; Neuronal Plasticity/*drug effects; Animals ; Behavior, Addictive/drug therapy ; Behavior, Addictive/physiopathology ; Brain Stem/metabolism ; Brain Stem/physiopathology ; Cholinergic Neurons/metabolism ; Humans ; Neuronal Plasticity/physiology
    • Abstract:
      Although the involvement and plasticity of the mesocorticolimbic dopamine (DA) system in cocaine-induced addiction have been studied extensively, the role of the brainstem cholinergic system in cocaine addiction remains largely unexplored. The laterodorsal tegmental nucleus (LDT) contains cholinergic neurons that innervate the ventral tegmental area (VTA) and is crucial for regulating the activity of VTA DA neurons, implying that LDT may also be associated with cocaine addiction. In this review, we summarize our recent findings showing that cholinergic transmission from the LDT to the VTA is involved in acquisition and expression of cocaine-induced conditioned place preference and that, after repeated cocaine exposures, these neurons exhibit synaptic plasticity, which is dependent on NMDA receptor activation, nitric oxide production, and the activity of medial prefrontal cortex. The findings strongly suggest that LDT cholinergic neurons may critically contribute to developing cocaine-induced addiction.
    • Accession Number:
      I5Y540LHVR (Cocaine)
    • Publication Date:
      Date Created: 20140621 Date Completed: 20140812 Latest Revision: 20140620
    • Publication Date:
      20240829
    • Accession Number:
      24946392