Expression of recombinant vaccines and antibodies in plants.

Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101590955 Publication Model: Print Cited Medium: Internet ISSN: 2167-9436 (Electronic) Linking ISSN: 21679436 NLM ISO Abbreviation: Monoclon Antib Immunodiagn Immunother Subsets: MEDLINE

Original Publication: New Rochelle, NY : Mary Ann Liebert, Inc.

Antibodies/*immunology ; Biopharmaceutics/*methods ; Biotechnology/*methods ; Plants/*immunology ; Recombinant Proteins/*immunology ; Vaccines, Synthetic/*immunology; Antibodies/metabolism ; Glycosylation ; Plants/metabolism ; Recombinant Proteins/metabolism ; Vaccines, Synthetic/metabolism

Plants are able to perform post-translational maturations of therapeutic proteins required for their functional biological activity and suitable in vivo pharmacokinetics. Plants can be a low-cost, large-scale production platform of recombinant biopharmaceutical proteins such as vaccines and antibodies. Plants, however, lack mechanisms of processing authentic human N-glycosylation, which imposes a major limitation in their use as an expression system for therapeutic glycoproducts. Efforts have been made to circumvent plant-specific N-glycosylation, as well as to supplement the plant's endogenous system with human glycosyltransferases for non-immunogenic and humanized N-glycan production. Herein we review studies on the potential of plants to serve as production systems for therapeutic and prophylactic biopharmaceuticals. We have especially focused on recombinant vaccines and antibodies and new expression strategies to overcome the existing problems associated with their production in plants.

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0 (Antibodies)
0 (Recombinant Proteins)
0 (Vaccines, Synthetic)

Date Created: 20140618 Date Completed: 20150219 Latest Revision: 20211021

20240829

PMC4063376

10.1089/mab.2014.0049

24937251