COX-2 Inhibitors — Lessons in Drug Safety.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Subject Terms:
      CYCLOOXYGENASE 2 inhibitors; GASTROINTESTINAL diseases; NONSTEROIDAL anti-inflammatory agents; ATHEROSCLEROSIS
    • Abstract:
      The article focuses on the authors' views on the use of cyclooxygenase-2 (COX-2) inhibitors. The authors say that COX-2 inhibitors, which were meant to deflect the gastrointestinal complications common to other nonsteroidal anti-inflammatory drugs, have shown serious adverse cardiovascular events. They suggest that apart from lacking the antiplatelet effects of aspirin, COX-2 inhibitors also impair one of the primary safeguards of the endothelium against platelet aggregation and atherosclerosis.