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PSEN1 and PSEN2 gene expression in Alzheimer's disease brain: a new approach.
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- Additional Information
- Source:
Publisher: IOS Press Country of Publication: Netherlands NLM ID: 9814863 Publication Model: Print Cited Medium: Internet ISSN: 1875-8908 (Electronic) Linking ISSN: 13872877 NLM ISO Abbreviation: J Alzheimers Dis Subsets: MEDLINE
- Publication Information:
Original Publication: Amsterdam ; Washington : IOS Press, c1998-
- Subject Terms:
- Abstract:
Presenilin 1 (PSEN1) and presenilin 2 (PSEN2) genes encode the major component of y-secretase, which is responsible for sequential proteolytic cleavages of amyloid precursor proteins and the subsequent formation of amyloid-β peptides. 150 RNA samples from the entorhinal cortex, auditory cortex and hippocampal regions of individuals with Alzheimer's disease (AD) and controls elderly subjects were analyzed with using real-time rtPCR. There were no differences between groups for PSEN1 expression. PSEN2 was significantly downregulated in the auditory cortex of AD patients when compared to controls and when compared to other brain regions of the patients. Alteration in PSEN2 expression may be a risk factor for AD.
- Contributed Indexing:
Keywords: Alzheimer's disease; brain; gene expression; presenilin-1; presenilin-2; γ-secretase
- Accession Number:
0 (Arabidopsis Proteins)
0 (Presenilin-1)
0 (Presenilin-2)
EC 5.4.- (Intramolecular Transferases)
EC 5.4.- (marneral synthase, Arabidopsis)
- Publication Date:
Date Created: 20140615 Date Completed: 20150825 Latest Revision: 20140917
- Publication Date:
20221213
- Accession Number:
10.3233/JAD-140033
- Accession Number:
24927704
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