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Photostabilization of endogenous porphyrins: excited state quenching by fused ring cyanoacrylates.
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- Author(s): Jockusch S;Jockusch S; Bonda C; Hu S
- Source:
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology [Photochem Photobiol Sci] 2014 Aug; Vol. 13 (8), pp. 1180-4.
- Publication Type:
Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
- Language:
English
- Additional Information
- Source:
Publisher: Springer Country of Publication: England NLM ID: 101124451 Publication Model: Print Cited Medium: Internet ISSN: 1474-9092 (Electronic) Linking ISSN: 1474905X NLM ISO Abbreviation: Photochem Photobiol Sci Subsets: MEDLINE
- Publication Information:
Publication: 2021- : [London] : Springer
Original Publication: Cambridge, UK : Royal Society of Chemistry, c2002-
- Subject Terms:
- Abstract:
Endogenous chromophores in human skin, when exposed to sunlight, generate harmful reactive oxygen species (ROS). Protoporphyrin IX (PpIX) is one of the common chromophores in human tissue. A series of aromatic cyanoacrylates were tested as quenchers of excited singlet and triplet states of PpIX. While the diaryl cyanoacrylate () did not quench excited singlet or triplet states of PpIX, some cyanoacrylates with fused aromatic rings showed excited singlet state quenching rate constants as high as 5 × 10(9) M(-1) s(-1) (acetonitrile solution). In addition, one of the fused ring cyanoacrylates () quenches PpIX triplet states with a rate constant of 3 × 10(9) M(-1) s(-1). The observed quenching rate constants correlated well with the suppression of singlet oxygen generation from PpIX under visible light exposure in the presence of dissolved oxygen. This photostabilization of endogenous chromophores can prevent or reduce ROS generation and perhaps constitute a new approach to mitigating cutaneous oxidative stress.
- Accession Number:
0 (Cyanoacrylates)
0 (Porphyrins)
0 (Protoporphyrins)
17778-80-2 (Singlet Oxygen)
C2K325S808 (protoporphyrin IX)
- Publication Date:
Date Created: 20140614 Date Completed: 20150512 Latest Revision: 20161125
- Publication Date:
20240829
- Accession Number:
10.1039/c4pp00090k
- Accession Number:
24926774
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