Comparison of three plasma sources for ambient desorption/ionization mass spectrometry.

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  • Author(s): McKay K;McKay K; Salter TL; Bowfield A; Walsh JL; Gilmore IS; Bradley JW
  • Source:
    Journal of the American Society for Mass Spectrometry [J Am Soc Mass Spectrom] 2014 Sep; Vol. 25 (9), pp. 1528-37. Date of Electronic Publication: 2014 Jun 04.
  • Publication Type:
    Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: ACS Publications Country of Publication: United States NLM ID: 9010412 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1123 (Electronic) Linking ISSN: 10440305 NLM ISO Abbreviation: J Am Soc Mass Spectrom Subsets: MEDLINE
    • Publication Information:
      Publication: 2020- : Washington, DC : ACS Publications
      Original Publication: New York, NY : Elsevier, c1990-
    • Subject Terms:
      Ions/*chemistry ; Plasma Gases/*chemistry ; Spectrometry, Mass, Electrospray Ionization/*instrumentation; Equipment Design ; Temperature
    • Abstract:
      Plasma-based desorption/ionization sources are an important ionization technique for ambient surface analysis mass spectrometry. In this paper, we compare and contrast three competing plasma based desorption/ionization sources: a radio-frequency (rf) plasma needle, a dielectric barrier plasma jet, and a low-temperature plasma probe. The ambient composition of the three sources and their effectiveness at analyzing a range of pharmaceuticals and polymers were assessed. Results show that the background mass spectrum of each source was dominated by air species, with the rf needle producing a richer ion spectrum consisting mainly of ionized water clusters. It was also seen that each source produced different ion fragments of the analytes under investigation: this is thought to be due to different substrate heating, different ion transport mechanisms, and different electric field orientations. The rf needle was found to fragment the analytes least and as a result it was able to detect larger polymer ions than the other sources.
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    • Accession Number:
      0 (Ions)
      0 (Plasma Gases)
    • Publication Date:
      Date Created: 20140605 Date Completed: 20151014 Latest Revision: 20211021
    • Publication Date:
      20221213
    • Accession Number:
      10.1007/s13361-014-0924-x
    • Accession Number:
      24894843