Microvascular obstruction assessed by 3-tesla magnetic resonance imaging in acute myocardial infarction is correlated with plasma troponin I levels.

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  • Additional Information
    • Source:
      Publisher: BioMed Central Country of Publication: England NLM ID: 100968539 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2261 (Electronic) Linking ISSN: 14712261 NLM ISO Abbreviation: BMC Cardiovasc Disord Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : BioMed Central, [2001-
    • Subject Terms:
      Magnetic Resonance Imaging, Cine*; Coronary Vessels/*pathology ; Microvessels/*pathology ; Myocardial Infarction/*diagnosis ; No-Reflow Phenomenon/*diagnosis ; Troponin I/*blood; Adult ; Aged ; Area Under Curve ; Biomarkers/blood ; Coronary Vessels/physiopathology ; Female ; Humans ; Male ; Microvessels/physiopathology ; Middle Aged ; Myocardial Infarction/blood ; Myocardial Infarction/pathology ; Myocardial Infarction/physiopathology ; Myocardium/pathology ; No-Reflow Phenomenon/blood ; No-Reflow Phenomenon/pathology ; No-Reflow Phenomenon/physiopathology ; Predictive Value of Tests ; Prognosis ; Prospective Studies ; ROC Curve ; Time Factors ; Ventricular Function, Left ; Ventricular Remodeling
    • Abstract:
      Background: Microvascular obstruction (MVO) at the acute phase of myocardial infarction (MI) is associated with poor prognosis. We aimed to evaluate the correlation between plasma cardiac troponin I (cTnI) at the acute phase of MI and extent of no-reflow, as assessed by 3-T cardiac magnetic resonance imaging (MRI). Secondly, we defined a cut-off value for cTnI predictive of no-reflow.
      Methods: 51 consecutive patients with no previous history of cardiovascular disease, presenting ST elevation MI within <12 h. Infarct size and extent of no-reflow were evaluated by 3-T MRI at day 5. Extent of no-reflow at 15 minutes (MVO) was correlated with cTnI at admission, 6, 12, 24, 48 and 72 hours. At 6 months, MRI was performed to evaluate the impact of MVO on LV remodeling.
      Results: MVO was diagnosed in 29 patients (57%). Extent of MVO was significantly correlated to peak troponin, cTnI (except admission values) and area under the curve. Using Receiver-operating characteristic (ROC) curve analysis, a cut-off cTnI value >89 ng/mL at 12 h seemed to best predict presence of early MVO (sensitivity 63%, specificity 88%). At 6 months, MVO was associated with left ventricular (LV) remodeling, resulting in higher LV volumes.
      Conclusion: There is a relationship between cTnI at the acute phase of AMI and extent of MVO as assessed by 3-T cardiac MRI. A cut-off cTnI value of 89 ng/mL at 12 h seems to best predict presence of MVO, which contributes to LV remodeling.
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    • Accession Number:
      0 (Biomarkers)
      0 (Troponin I)
    • Publication Date:
      Date Created: 20140603 Date Completed: 20150120 Latest Revision: 20211021
    • Publication Date:
      20231215
    • Accession Number:
      PMC4013057
    • Accession Number:
      10.1186/1471-2261-14-57
    • Accession Number:
      24886208