Human serum acylcarnitine profiles in different glucose tolerance states.

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  • Author(s): Zhang X;Zhang X; Zhang C; Zhang C; Chen L; Chen L; Han X; Han X; Ji L; Ji L
  • Source:
    Diabetes research and clinical practice [Diabetes Res Clin Pract] 2014 Jun; Vol. 104 (3), pp. 376-82. Date of Electronic Publication: 2014 Apr 28.
  • Publication Type:
    Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 8508335 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8227 (Electronic) Linking ISSN: 01688227 NLM ISO Abbreviation: Diabetes Res Clin Pract Subsets: MEDLINE
    • Publication Information:
      Publication: 1993- : Limerick : Elsevier Scientific Publishers
      Original Publication: Amsterdam : Elsevier Science Publishers B.V., c1985-
    • Subject Terms:
      Biomarkers/*metabolism ; Blood Glucose/*analysis ; Carnitine/*analogs & derivatives ; Diabetes Mellitus, Type 2/*blood ; Glucose Intolerance/*blood ; Prediabetic State/*blood; Carnitine/blood ; Chromatography, Liquid ; Diabetes Mellitus, Type 2/diagnosis ; Fasting/blood ; Female ; Glucose Intolerance/diagnosis ; Glucose Tolerance Test ; Humans ; Male ; Middle Aged ; Oxidation-Reduction ; Prediabetic State/diagnosis ; Spectrometry, Mass, Electrospray Ionization
    • Abstract:
      Aims: To understand the relationship between serum acylcarnitine profiles and glucose tolerance status.
      Methods: We analyzed 61 subjects who were divided into three groups based on their glucose tolerance status: normal glucose tolerance (NGT; n=20,M/F=9/11, mean age 48 years), pre-diabetes (Pre-DM; n=20,M/F=11/9, mean age 51 years), or newly diagnosed type 2 diabetes mellitus (T2DM; n=21,M/F=8/13, mean age 49 years). Fasting serum free carnitine and acylcarnitine concentrations were determined using isotope dilution electrospray ionization mass spectrometry coupled with high performance liquid chromatography.
      Results: In comparison with NGT subjects, Pre-DM and type 2 diabetes subjects showed serum metabonomic changes highlighted by dysregulation of mitochondrial fatty acid combustion. Of the long-chain carnitine esters, significantly higher palmitoylcarnitine (C16), 3-OH-hexadecanoylcarnitine (C16-OH), carnitine C20, carnitine C22, and carnitine C24 concentrations (all P<0.05) were noted in the newly diagnosed type 2 diabetes group, and even the pre-diabetes group.
      Conclusions: This research provides further evidence of alterations in serum acylcarnitine profiles being associated with worse glucoseintolerance. The findings may suggest different degrees of involvement of dysregulated mitochondrial function and incomplete long-chain fatty acid oxidation pathways in the natural course of type 2 diabetes.
      (Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)
    • Contributed Indexing:
      Keywords: Carnitine; Mass spectrometry; Metabolism; Pre-diabetes; Type 2 diabetes
    • Accession Number:
      0 (Biomarkers)
      0 (Blood Glucose)
      0 (acylcarnitine)
      S7UI8SM58A (Carnitine)
    • Publication Date:
      Date Created: 20140520 Date Completed: 20141118 Latest Revision: 20181202
    • Publication Date:
      20240628
    • Accession Number:
      10.1016/j.diabres.2014.04.013
    • Accession Number:
      24837145