[Platelets in the pathogenesis of solid tumors].

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  • Additional Information
    • Transliterated Title:
      Krevní destičky v patogenezia léčbě solidních nádorů
    • Source:
      Publisher: Ceskoslovenska Lekarska Spolecnost Country of Publication: Czech Republic NLM ID: 0004743 Publication Model: Print Cited Medium: Print ISSN: 0008-7335 (Print) Linking ISSN: 00087335 NLM ISO Abbreviation: Cas Lek Cesk Subsets: MEDLINE
    • Publication Information:
      Original Publication: Praha : Ceskoslovenska Lekarska Spolecnost
    • Subject Terms:
      Neoplasm Metastasis*; Blood Platelets/*physiology ; Neoplasms/*blood ; Platelet Aggregation/*physiology; Cell Adhesion ; Cell-Derived Microparticles/metabolism ; Humans ; Intercellular Signaling Peptides and Proteins/metabolism ; Neoplasms/pathology ; Neovascularization, Pathologic/blood ; Tumor Microenvironment
    • Abstract:
      Cancer cells trigger platelet aggregation. Reciprocally, platelet aggregation promotes tumor growth and metastasis. Within the tumor microenvironment, platelet regulates tumor growth via several mechanisms involving stimulation of angiogenesis, inflammation, coagulation, and stabilizing of vessel wall. In circulation, cancer cells coated by platelets can travel to metastatic site protected from intravascular shear forces and from immune surveillance. Finally, platelets facilitate adhesion of tumor cells and formation of the metastatic niche. Platelet-derived microparticles contain growth factors contributing to tumor angiogenesis. On the other hand, platelets can selectively release anti-angiogenic factors in a process connected to tumor dormancy. Therapeutical inhibition of platelet aggregation prevents tumor development in certain tumor types and may contribute to better cancer outcome.
    • Grant Information:
      R01 GM093050 United States GM NIGMS NIH HHS
    • Accession Number:
      0 (Intercellular Signaling Peptides and Proteins)
    • Publication Date:
      Date Created: 20140507 Date Completed: 20151030 Latest Revision: 20220408
    • Publication Date:
      20240829
    • Accession Number:
      24797778