Structure-activity relationship studies on neuroactive steroids in memory, alcohol and stress-related functions: a crucial benefit from endogenous level analysis.

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  • Author(s): Vallée M;Vallée M
  • Source:
    Psychopharmacology [Psychopharmacology (Berl)] 2014 Sep; Vol. 231 (17), pp. 3243-55. Date of Electronic Publication: 2014 Apr 30.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7608025 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2072 (Electronic) Linking ISSN: 00333158 NLM ISO Abbreviation: Psychopharmacology (Berl) Subsets: MEDLINE
    • Publication Information:
      Original Publication: Berlin, New York, Springer-Verlag.
    • Subject Terms:
      Central Nervous System Depressants/*pharmacology ; Ethanol/*pharmacology ; Memory/*drug effects ; Neurotransmitter Agents/*pharmacology ; Stress, Psychological/*metabolism ; Stress, Psychological/*psychology; Animals ; Humans ; Neurotransmitter Agents/chemistry ; Neurotransmitter Agents/metabolism ; Structure-Activity Relationship
    • Abstract:
      Rationale: New research findings in the field of neuroactive steroids strongly suggest that to understand their role in physiopathology, it is essential to accurately measure their tissue levels. Through his broad chemical expertise and extensive knowledge of steroids, Dr. Robert H. Purdy pioneered structure-activity relationship studies on these compounds and developed innovative detection assays that are essential to assess their function in biological tissues.
      Objective: The goal of the present paper is to point out the specific contributions of Dr. Purdy and his collaborators to the current knowledge on the role of neuroactive steroids in the modulation of memory and alcohol- and stress-related effects with particular emphasis on the detection assays he developed to assess their endogenous levels. Reviewed here are the major results as well as the original and valuable methodological strategies issued by the long-term collaboration between Dr Purdy and many scientists worldwide on the investigation of the structure-activity relationship of neuroactive steroids.
      Results: Altogether, the data presented herein put forward the original notion that knowledge of the chemical structure of steroids is essential for their detection and the understanding of their role in physiological and pathological conditions, including the stress response.
      Conclusions: The current challenge is to identify and quantify using appropriate methods neuroactive steroids in the context of both animal and clinical studies in order to reveal how their levels change under physiological and disease states. Dr. Purdy passed away in September 2012, but scientists all over the world will always be grateful for his pioneering work on steroid chemistry and for his great enthusiasm in research.
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    • Accession Number:
      0 (Central Nervous System Depressants)
      0 (Neurotransmitter Agents)
      3K9958V90M (Ethanol)
    • Publication Date:
      Date Created: 20140501 Date Completed: 20150602 Latest Revision: 20211021
    • Publication Date:
      20231215
    • Accession Number:
      10.1007/s00213-014-3593-3
    • Accession Number:
      24781520