Community-based network study of protein-carbohydrate interactions in plant lectins using glycan array data.

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  • Author(s): Malik A;Malik A; Lee J; Lee J; Lee J; Lee J
  • Source:
    PloS one [PLoS One] 2014 Apr 22; Vol. 9 (4), pp. e95480. Date of Electronic Publication: 2014 Apr 22 (Print Publication: 2014).
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
    • Publication Information:
      Original Publication: San Francisco, CA : Public Library of Science
    • Subject Terms:
      Glycomics* ; Protein Interaction Maps*; Microarray Analysis/*methods ; Plant Lectins/*metabolism ; Polysaccharides/*metabolism; Cluster Analysis ; Fluorescence ; Protein Binding
    • Abstract:
      Lectins play major roles in biological processes such as immune recognition and regulation, inflammatory responses, cytokine signaling, and cell adhesion. Recently, glycan microarrays have shown to play key roles in understanding glycobiology, allowing us to study the relationship between the specificities of glycan binding proteins and their natural ligands at the omics scale. However, one of the drawbacks in utilizing glycan microarray data is the lack of systematic analysis tools to extract information. In this work, we attempt to group various lectins and their interacting carbohydrates by using community-based analysis of a lectin-carbohydrate network. The network consists of 1119 nodes and 16769 edges and we have identified 3 lectins having large degrees of connectivity playing the roles of hubs. The community based network analysis provides an easy way to obtain a general picture of the lectin-glycan interaction and many statistically significant functional groups.
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    • Accession Number:
      0 (Plant Lectins)
      0 (Polysaccharides)
    • Publication Date:
      Date Created: 20140424 Date Completed: 20150115 Latest Revision: 20211021
    • Publication Date:
      20231215
    • Accession Number:
      PMC3995809
    • Accession Number:
      10.1371/journal.pone.0095480
    • Accession Number:
      24755681