Programmed cell death controlled by ANAC033/SOMBRERO determines root cap organ size in Arabidopsis.

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  • Additional Information
    • Source:
      Publisher: Cell Press Country of Publication: England NLM ID: 9107782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0445 (Electronic) Linking ISSN: 09609822 NLM ISO Abbreviation: Curr Biol Subsets: MEDLINE
    • Publication Information:
      Publication: Cambridge, MA : Cell Press
      Original Publication: London, UK : Current Biology Ltd., c1991-
    • Subject Terms:
      Arabidopsis/*growth & development ; Arabidopsis Proteins/*genetics ; Arabidopsis Proteins/*metabolism ; Cell Death/*genetics ; Deoxyribonucleases/*metabolism ; Plant Root Cap/*growth & development ; Transcription Factors/*genetics; Autolysis ; Cell Proliferation ; DNA Fragmentation ; Deoxyribonucleases/genetics ; Gene Expression Regulation, Plant ; Homeostasis ; Organ Size ; Plant Development ; Plant Root Cap/physiology ; Transcription, Genetic
    • Abstract:
      Background: The root cap is a plant organ that ensheathes the meristematic stem cells at the root tip. Unlike other plant organs, the root cap shows a rapid cellular turnover, balancing constant cell generation by specific stem cells with the disposal of differentiated cells at the root cap edge. This cellular turnover is critical for the maintenance of root cap size and its position around the growing root tip, but how this is achieved and controlled in the model plant Arabidopsis thaliana remains subject to contradictory hypotheses.
      Results: Here, we show that a highly organized cell death program is the final step of lateral root cap differentiation and that preparation for cell death is transcriptionally controlled by ANAC033/SOMBRERO. Precise timing of cell death is critical for the elimination of root cap cells before they fully enter the root elongation zone, which in turn is important in order to allow optimal root growth. Root cap cell death is followed by a rapid cell-autonomous corpse clearance and DNA fragmentation dependent on the S1-P1 type nuclease BFN1.
      Conclusions: Based on these results, we propose a novel concept in plant development that recognizes programmed cell death as a mechanism for maintaining organ size and tissue homeostasis in the Arabidopsis root cap.
      (Copyright © 2014 Elsevier Ltd. All rights reserved.)
    • Comments:
      Comment in: Curr Biol. 2014 May 5;24(9):R374-6. (PMID: 24801191)
    • Accession Number:
      0 (Arabidopsis Proteins)
      0 (BFN1 protein, Arabidopsis)
      0 (SOMBRERO protein, Arabidopsis)
      0 (Transcription Factors)
      EC 3.1.- (Deoxyribonucleases)
    • Publication Date:
      Date Created: 20140415 Date Completed: 20150113 Latest Revision: 20140507
    • Publication Date:
      20231215
    • Accession Number:
      10.1016/j.cub.2014.03.025
    • Accession Number:
      24726156