Jagged1 is necessary for postnatal and adult neurogenesis in the dentate gyrus.

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  • Author(s): Lavado A;Lavado A; Oliver G; Oliver G
  • Source:
    Developmental biology [Dev Biol] 2014 Apr 01; Vol. 388 (1), pp. 11-21. Date of Electronic Publication: 2014 Feb 13.
  • Publication Type:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: United States NLM ID: 0372762 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-564X (Electronic) Linking ISSN: 00121606 NLM ISO Abbreviation: Dev Biol Subsets: MEDLINE
    • Publication Information:
      Publication: San Diego, CA : Elsevier
      Original Publication: New York.
    • Subject Terms:
      Gene Expression Regulation, Developmental*; Calcium-Binding Proteins/*physiology ; Dentate Gyrus/*cytology ; Intercellular Signaling Peptides and Proteins/*physiology ; Membrane Proteins/*physiology ; Neurogenesis/*physiology ; Receptor, Notch1/*physiology; Animals ; Calcium-Binding Proteins/genetics ; Cell Proliferation ; Dentate Gyrus/embryology ; Dentate Gyrus/pathology ; Gene Deletion ; Immunohistochemistry ; In Situ Nick-End Labeling ; Intercellular Signaling Peptides and Proteins/genetics ; Jagged-1 Protein ; Ligands ; Membrane Proteins/genetics ; Mice ; Microscopy, Fluorescence ; Mutation ; Neural Stem Cells/cytology ; Receptor, Notch1/genetics ; Serrate-Jagged Proteins ; Stem Cells/cytology ; Tamoxifen/chemistry
    • Abstract:
      Understanding the mechanisms that control the maintenance of neural stem cells is crucial for the study of neurogenesis. In the brain, granule cell neurogenesis occurs during development and adulthood, and the generation of new neurons in the adult subgranular zone of the dentate gyrus contributes to learning. Notch signaling plays an important role during postnatal and adult subgranular zone neurogenesis, and it has been suggested as a potential candidate to couple cell proliferation with stem cell maintenance. Here we show that conditional inactivation of Jagged1 affects neural stem cell maintenance and proliferation during postnatal and adult neurogenesis of the subgranular zone. As a result, granule cell production is severely impaired. Our results provide additional support to the proposal that Notch/Jagged1 activity is required for neural stem cell maintenance during granule cell neurogenesis and suggest a link between maintenance and proliferation of these cells during the early stages of neurogenesis.
      (Copyright © 2014 Elsevier Inc. All rights reserved.)
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    • Grant Information:
      P30 CA021765 United States CA NCI NIH HHS; R01 EY012162 United States EY NEI NIH HHS; CA-21765 United States CA NCI NIH HHS; EY12162 United States EY NEI NIH HHS
    • Contributed Indexing:
      Keywords: Dentate gyrus; Jagged1; Progenitors
    • Accession Number:
      0 (Calcium-Binding Proteins)
      0 (Intercellular Signaling Peptides and Proteins)
      0 (Jag1 protein, mouse)
      0 (Jagged-1 Protein)
      0 (Ligands)
      0 (Membrane Proteins)
      0 (Notch1 protein, mouse)
      0 (Receptor, Notch1)
      0 (Serrate-Jagged Proteins)
      094ZI81Y45 (Tamoxifen)
    • Publication Date:
      Date Created: 20140218 Date Completed: 20140508 Latest Revision: 20211021
    • Publication Date:
      20231215
    • Accession Number:
      PMC4009513
    • Accession Number:
      10.1016/j.ydbio.2014.02.004
    • Accession Number:
      24530424