Severe obesity, heart disease, and death among white, African American, and Hispanic postmenopausal women.

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  • Additional Information
    • Source:
      Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101264860 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1930-739X (Electronic) Linking ISSN: 19307381 NLM ISO Abbreviation: Obesity (Silver Spring) Subsets: MEDLINE
    • Publication Information:
      Publication: 2013- : Malden, MA : John Wiley & Sons
      Original Publication: Silver Spring, MD : NAASO, the Obesity Society, c2006-
    • Subject Terms:
      Black or African American* ; Hispanic or Latino* ; Postmenopause* ; White People*; Heart Diseases/*epidemiology ; Obesity, Morbid/*epidemiology; Aged ; Body Mass Index ; Calcium, Dietary/administration & dosage ; Dietary Supplements ; Female ; Follow-Up Studies ; Hormones/therapeutic use ; Humans ; Incidence ; Middle Aged ; Proportional Hazards Models ; Randomized Controlled Trials as Topic ; Risk Factors ; Vitamin D/administration & dosage
    • Abstract:
      Objective: To compare mortality, nonfatal coronary heart disease (CHD), and congestive heart failure (CHF) risk across BMI categories in white, African American, and Hispanic women, with a focus on severe obesity (BMI ≥ 40), and examine heterogeneity in weight-related CHD risk.
      Methods: Among 156,775 Women's Health Initiative observational study and clinical trial participants (September 1993-12 September 2005), multivariable Cox models estimated relative risk for mortality, CHD, and CHF. CHD incidence was calculated by anthropometry, race, and cardiovascular risk factors (CVRF).
      Results: Mortality, nonfatal CHD, and CHF incidence generally rose with BMI category. For severe obesity versus normal BMI, hazard ratios (HRs, 95% confidence interval) for mortality were 1.97 (1.77-2.20) in white, 1.55 (1.20-2.00) in African American, and 2.59 (1.55-4.31) in Hispanic women; for CHD, HRs were 2.05 (1.80-2.35), 2.24 (1.57-3.19), and 2.95 (1.60-5.41) respectively; for CHF, HRs were 5.01 (4.33-5.80), 3.60 (2.30-5.62), and 6.05 (2.49-14.69). CVRF variation resulted in substantial variation in CHD rates across BMI categories, even in severe obesity. CHD incidence was similar by race/ethnicity when differences in BMI or CVRF were accounted for.
      Conclusions: Severe obesity increases mortality, nonfatal CHD, and CHF risk in women of diverse race/ethnicity. CVRF heterogeneity contributes to variation in CHD incidence even in severe obesity.
      (Copyright © 2012 The Obesity Society.)
    • Grant Information:
      K08 DK067192 United States DK NIDDK NIH HHS; 1 K08 DK067192-01 United States DK NIDDK NIH HHS
    • Contributed Indexing:
      Keywords: cardiovascular diseases/epidemiology; cardiovascular diseases/etiology; longitudinal studies; obesity, morbid/complications; obesity, morbid/epidemiology; obesity/epidemiology, obesity/complications
    • Accession Number:
      0 (Calcium, Dietary)
      0 (Hormones)
      1406-16-2 (Vitamin D)
    • Publication Date:
      Date Created: 20140205 Date Completed: 20141103 Latest Revision: 20221207
    • Publication Date:
      20240628
    • Accession Number:
      10.1002/oby.20224
    • Accession Number:
      24493096