The personal human oral microbiome obscures the effects of treatment on periodontal disease.

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  • Additional Information
    • Source:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
    • Publication Information:
      Original Publication: San Francisco, CA : Public Library of Science
    • Subject Terms:
      Phylogeny*; Fusobacterium/*classification ; Microbiota/*genetics ; Periodontitis/*microbiology ; Prevotella/*classification; Adult ; Anti-Bacterial Agents/therapeutic use ; Case-Control Studies ; Fusobacterium/genetics ; Fusobacterium/isolation & purification ; High-Throughput Nucleotide Sequencing ; Humans ; Indians, North American ; Periodontitis/drug therapy ; Periodontitis/ethnology ; Periodontium/drug effects ; Periodontium/microbiology ; Prevotella/genetics ; Prevotella/isolation & purification ; Severity of Illness Index
    • Abstract:
      Periodontitis is a progressive disease of the periodontium with a complex, polymicrobial etiology. Recent Next-Generation Sequencing (NGS) studies of the microbial diversity associated with periodontitis have revealed strong, community-level differences in bacterial assemblages associated with healthy or diseased periodontal sites. In this study, we used NGS approaches to characterize changes in periodontal pocket bacterial diversity after standard periodontal treatment. Despite consistent changes in the abundance of certain taxa in individuals whose condition improved with treatment, post-treatment samples retained the highest similarity to pre-treatment samples from the same individual. Deeper phylogenetic analysis of periodontal pathogen-containing genera Prevotella and Fusobacterium found both unexpected diversity and differential treatment response among species. Our results highlight how understanding interpersonal variability among microbiomes is necessary for determining how polymicrobial diseases respond to treatment and disturbance.
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    • Grant Information:
      U26IHS300292 United States PHS HHS
    • Accession Number:
      0 (Anti-Bacterial Agents)
    • Publication Date:
      Date Created: 20140204 Date Completed: 20140929 Latest Revision: 20220316
    • Publication Date:
      20221213
    • Accession Number:
      PMC3906071
    • Accession Number:
      10.1371/journal.pone.0086708
    • Accession Number:
      24489772