Transcription of the SCL/TAL1 interrupting Locus (Stil) is required for cell proliferation in adult Zebrafish Retinas.

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  • Additional Information
    • Source:
      Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
    • Publication Information:
      Publication: 2021- : [New York, NY] : Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology
      Original Publication: Baltimore, MD : American Society for Biochemistry and Molecular Biology
    • Subject Terms:
      Cell Proliferation*; Basic Helix-Loop-Helix Transcription Factors/*physiology ; Hedgehog Proteins/*metabolism ; Proto-Oncogene Proteins/*physiology ; Retina/*pathology ; Zebrafish/*metabolism ; Zebrafish Proteins/*metabolism ; Zebrafish Proteins/*physiology; Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Ependymoglial Cells/drug effects ; Ependymoglial Cells/metabolism ; Ependymoglial Cells/pathology ; Gene Expression ; Gene Knockdown Techniques ; Hedgehog Proteins/genetics ; Oxidopamine/pharmacology ; Proto-Oncogene Proteins/genetics ; Repressor Proteins/genetics ; Retina/drug effects ; Retina/metabolism ; Retinal Degeneration/chemically induced ; Retinal Degeneration/pathology ; Retinal Rod Photoreceptor Cells/drug effects ; Retinal Rod Photoreceptor Cells/metabolism ; Retinal Rod Photoreceptor Cells/pathology ; Signal Transduction ; T-Cell Acute Lymphocytic Leukemia Protein 1 ; Zebrafish/genetics ; Zebrafish Proteins/genetics
    • Abstract:
      The human oncogene SCL/TAL1 interrupting locus (Stil) is highly conserved in vertebrate species. Previously, we identified a homolog of the Stil gene in zebrafish mutant (night blindness b, nbb), which showed neural defects in the retina (e.g. dopaminergic cell degeneration and/or lack of regeneration). In this research, we examined the roles of Stil in cell proliferation after degeneration in adult zebrafish retinas. We demonstrated that knockdown of Stil gene expression or inhibition of Sonic hedgehog (Shh) signaling transduction decreases the rate of cell proliferation. In contrast, activation of Shh signal transduction promotes cell proliferation. In nbb(+/-) retinas, inhibition of SUFU (a repressor in the Shh pathway) rescues the defects in cell proliferation due to down-regulation of Stil gene expression. The latter data suggest that Stil play a role in cell proliferation through the Shh signal transduction pathway.
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    • Grant Information:
      R01 EY013147 United States EY NEI NIH HHS; R01 EY018417 United States EY NEI NIH HHS; R01-EY013147 United States EY NEI NIH HHS; R01-EY018417 United States EY NEI NIH HHS
    • Contributed Indexing:
      Keywords: Cell Proliferation; Neurons; Oncogene; Retina; Zebrafish
    • Accession Number:
      0 (Basic Helix-Loop-Helix Transcription Factors)
      0 (Hedgehog Proteins)
      0 (Proto-Oncogene Proteins)
      0 (Repressor Proteins)
      0 (Shha protein, zebrafish)
      0 (Sufu protein, zebrafish)
      0 (T-Cell Acute Lymphocytic Leukemia Protein 1)
      0 (Zebrafish Proteins)
      0 (tal1 protein, zebrafish)
      8HW4YBZ748 (Oxidopamine)
    • Publication Date:
      Date Created: 20140129 Date Completed: 20140624 Latest Revision: 20211021
    • Publication Date:
      20240829
    • Accession Number:
      PMC3945354
    • Accession Number:
      10.1074/jbc.M113.506295
    • Accession Number:
      24469449