Homocysteine levels are inversely associated with capillary density in men, not in premenopausal women.

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  • Additional Information
    • Source:
      Publisher: Wiley Country of Publication: England NLM ID: 0245331 Publication Model: Print Cited Medium: Internet ISSN: 1365-2362 (Electronic) Linking ISSN: 00142972 NLM ISO Abbreviation: Eur J Clin Invest Subsets: MEDLINE
    • Publication Information:
      Publication: Oxford : Wiley
      Original Publication: Berlin, New York, Springer-Verlag, on behalf of the European Society for Clinical Investigation.
    • Subject Terms:
      Capillaries/*physiology ; Fingers/*blood supply ; Homocysteine/*blood ; Microcirculation/*physiology ; Premenopause/*blood; Adult ; Blood Pressure ; Body Mass Index ; Cohort Studies ; Cross-Sectional Studies ; Female ; Humans ; Linear Models ; Male ; Microscopic Angioscopy ; Premenopause/physiology ; Sex Factors
    • Abstract:
      Background: Homocysteine is an independent predictor of cardiovascular risk. The mechanisms underlying this link are not fully elucidated. Whereas the role of vascular dysfunction in conduit arteries is extensively studied, the role of the microcirculation in this relationship is largely unexplored. We assessed the relationship between homocysteine levels and microvascular structure and function in a healthy, population-based cohort.
      Materials and Methods: We cross-sectionally studied 260 participants (aged 42 years, 47% men) of the Amsterdam Growth and Health Longitudinal Study. Nailfold videocapillaroscopy was used to assess capillary density at baseline, during venous occlusion and during peak reactive hyperaemia. The relationship between tertiles of homocysteine and microvascular outcomes was evaluated using linear regression analyses, with adjustment for BMI and blood pressure. Stratified analyses were performed for men and women.
      Results: In men, we observed a negative, nonlinear relationship between homocysteine and baseline capillary density, showing a lower capillary density in the highest tertile of homocysteine [adjusted B -8.65 capillaries/mm(2) (95%-CI: -16.05 to -1.25); P = 0.02]. In women, no significant associations were found between homocysteine and microvascular outcomes.
      Conclusions: In men, higher homocysteine levels are associated with a reduction in basal perfusion of skin capillaries. This finding provides a novel potential explanation for how homocysteine influences cardiovascular disease risk.
      (© 2014 Stichting European Society for Clinical Investigation Journal Foundation.)
    • Contributed Indexing:
      Keywords: Capillaroscopy; cardiovascular diseases; homocysteine; microcirculation
    • Accession Number:
      0LVT1QZ0BA (Homocysteine)
    • Publication Date:
      Date Created: 20140116 Date Completed: 20141022 Latest Revision: 20220321
    • Publication Date:
      20240829
    • Accession Number:
      10.1111/eci.12240
    • Accession Number:
      24422875