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Inhibition of melanin content by Punicalagins in the super fruit pomegranate (Punica granatum).
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- Additional Information
- Source:
Publisher: Society of Cosmetic Chemists Country of Publication: United States NLM ID: 9814276 Publication Model: Print Cited Medium: Print ISSN: 1525-7886 (Print) Linking ISSN: 15257886 NLM ISO Abbreviation: J Cosmet Sci Subsets: MEDLINE
- Publication Information:
Original Publication: New York, NY : Society of Cosmetic Chemists, 1998-
- Subject Terms:
- Abstract:
Current efforts to develop effective skin lightening products through the inhibition of melanin production have focused on compounds that inhibit the function and activity of tyrosinase, the rate-limiting enzyme in the melanin biosynthesis pathway. Synthetic tyrosinase inhibitors, such as hydroquinone, kojic acid, and arbutin, have been reported to cause skin irritation or acute dermatitis, raising concerns about the safety of these compounds. As a result, there is a need for safe natural ingredients that show effective skin lightening. In this report, we have identified a natural ingredient, pomegranate fruit extract, that inhibits melanin production in melanocytes and shows potential for use as a cosmetic skin lightening agent. In addition, we have identified a polyphenolic compound, punicalagins, as the active melanin inhibitor in pomegranate fruit extract based on its capacity to directly inhibit melanin production.
- Accession Number:
0 (Hydrolyzable Tannins)
0 (Melanins)
0 (Plant Extracts)
0 (Skin Lightening Preparations)
19YRN3ZS9P (Ellagic Acid)
65995-63-3 (punicalagin)
EC 1.14.18.1 (Monophenol Monooxygenase)
- Publication Date:
Date Created: 20140109 Date Completed: 20140220 Latest Revision: 20191210
- Publication Date:
20231215
- Accession Number:
24397882
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