Alteration of cytokine production during visceral larva migrans by Toxascaris leonina in mice.

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  • Author(s): Kang SA;Kang SA; Park MK; Cho MK; Yu HS
  • Source:
    The Korean journal of parasitology [Korean J Parasitol] 2013 Oct; Vol. 51 (5), pp. 583-8. Date of Electronic Publication: 2013 Oct 31.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Korean Society for Parasitology Country of Publication: Korea (South) NLM ID: 9435800 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1738-0006 (Electronic) Linking ISSN: 00234001 NLM ISO Abbreviation: Korean J Parasitol Subsets: MEDLINE
    • Publication Information:
      Original Publication: Seoul, Korea : Korean Society for Parasitology, c1993-2022.
    • Subject Terms:
      Cytokines/*metabolism ; Interleukins/*metabolism ; Larva Migrans, Visceral/*immunology ; Toxascaris/*immunology; Animals ; Brain/parasitology ; Female ; Gene Expression Regulation ; Heart/parasitology ; Intestines/parasitology ; Larva Migrans, Visceral/parasitology ; Liver/parasitology ; Lung/parasitology ; Lung/pathology ; Mice ; Mice, Inbred C57BL ; Muscles/parasitology ; Spleen/parasitology ; Th1 Cells/immunology ; Th17 Cells/immunology ; Th2 Cells/immunology ; Thymic Stromal Lymphopoietin
    • Abstract:
      To determine alteration of immune responses during visceral larva migrans (VLM) caused by Toxascaris leonina at several time points, we experimentally infected mice with embryonated eggs of T. leonina and measured T-helper (Th) cell-related serial cytokine production after infection. At day 5 post infection (PI), most larvae were detected from the lungs, spleen, intestine, and muscle. Expression of thymic stromal lymphopoietin (TSLP) and CCL11 (eotaxin) showed a significant increase in most infected organs, except the intestine. However, expression of the CXCL1 (Gro-α) gene was most highly enhanced in the intestine at day 14 PI. Th1-related cytokine secretion of splenocytes showed increases at day 28 PI, and the level showed a decrease at day 42 PI. Th2-related cytokine secretion of splenocytes also showed an increase after infection; in particular, IL-5 level showed a significant increase at day 14 PI, and the level showed a decrease at day 28 PI. However, levels of Th17-related cytokines, IL-6 and IL-17A, showed gradual increases until day 42 PI. In conclusion, Th1, Th2, and Th17-related cytokine production might be important in immune responses against T. leonina VLM in experimental mice.
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    • Contributed Indexing:
      Keywords: Th1; Th17; Th2; Toxascaris leonina; cytokine; visceral larva migrans (VLM)
    • Accession Number:
      0 (Cytokines)
      0 (Interleukins)
      GT0IL38SP4 (Thymic Stromal Lymphopoietin)
    • Publication Date:
      Date Created: 20131212 Date Completed: 20150417 Latest Revision: 20221207
    • Publication Date:
      20221213
    • Accession Number:
      PMC3857509
    • Accession Number:
      10.3347/kjp.2013.51.5.583
    • Accession Number:
      24327787