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Dietary fish oil increases the number of splenic macrophages secreting TNF-alpha and IL-10 but decreases the secretion of these cytokines by splenic T cells from mice.
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- Author(s): Petursdottir, Dagbjort H.; Hardardottir, Ingibjorg
- Source:
Journal of Nutrition. Mar2007, Vol. 137 Issue 3, p665-670. 6p. 1 Chart, 4 Graphs. - Source:
- Additional Information
- Subject Terms: MACROPHAGES; CYTOKINES; ENZYME-linked immunosorbent assay; IMMUNOREGULATION; FISH oils; MARINE animal oils; CELLULAR immunity; T cells; BIOLOGICAL transport; ANIMAL experimentation; COMPARATIVE studies; CORN oil; FAT content of food; INTERLEUKINS; RESEARCH methodology; MEDICAL cooperation; MICE; PLANT proteins; RESEARCH; SPLEEN; TUMOR necrosis factors; EVALUATION research; LIPOPOLYSACCHARIDES
- Abstract: Dietary fish oil has immunomodulatory effects that are partly mediated by its effects on cytokine secretion. In this paper, we examine whether dietary fish oil has different effects on cytokine secretion by T cells and macrophages. Female BalbC mice were fed diets supplemented with 18% fish oil + 2% corn oil or 20% corn oil. Concanavalin A (ConA)- and LPS-induced TNF-alpha and IL-10 secretion by splenocytes was examined using ELISA. Dietary fish oil decreased ConA induced-, but increased LPS-induced, TNF-alpha and IL-10 secretion by total murine splenocytes. Dietary fish oil increased the number of splenocytes secreting TNF-alpha and IL-10, following stimulation with LPS, by 123 and 38%, respectively, but did not affect cytokine secretion by each cell, as determined using enzyme-linked immunospot. Spleens from mice fed the fish oil diet had over 2-fold higher proportion of macrophages with high expression of CD11b than spleens from mice fed the corn oil diet. In addition, fish oil increased the proportion of total and CD11b(+) splenocytes that expressed the LPS receptor complex molecules, CD14 and toll-like receptor (TLR)4/myeloid differentiation factor-2 (MD-2), by 85 and 28%, respectively. The increased proportion of macrophages expressing the LPS receptor complex molecules, CD14 and TLR4/MD-2, in spleens from mice fed the fish oil diet may explain the increased number of cells that secreted the cytokines after LPS stimulation. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Journal of Nutrition is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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